ASSESSMENT OF SERUM INTERLEUKIN-10 LEVEL IN CHRONIC HEPATITIS C PATIENTS TREATED WITH PEGYLATED INTERFERON AND RIBAVIRIN | ||||
| Kafrelsheikh Veterinary Medical Journal | ||||
| Article 8, Volume 12, Issue 2, October 2014, Page 129-151 PDF (819.43 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/kvmj.2014.110156 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| S. Z. Abd al aziz* 1; Hannan A. Soliman1; S. R., Abdel raheim2; A. M. Okasha2; Nilly Helmy Abdalla3 | ||||
| 1Department of chemistry, Faculty of Science, Beni-Suef University | ||||
| 2Department of Biochemistry, Faculty of Medicine, Minia University, Egypt | ||||
| 3Department of Internal Medicine, Faculty of Medicine, Beni-Suef University | ||||
| Abstract | ||||
| Hepatitis C virus (HCV) infection is a major health problem. Egypt has the highest prevalence worldwide. Currently, combined pegylated interferon and ribavirin therapy is the standard treatment but the outcome is not satisfactory. The present study aimed To assess the possible association of serum IL-10 level, SOD activity in erythrocyte lysate and plasma MDA level and response to combined interferon α-2a and ribavirin therapy in chronic HCV infection. In (Group < /em> I) who were not responded to pegylated interferon and rebavirin combination therapy we found the level of serum IL-10 and plasma MDA still high while antioxidant enzyme SOD activity reduced. While in (Group II) who responded to pegylated interferon and rebavirin combination therapy a circulating serum IL-10 and plasma MDA levels reduced but erythrocyte antioxidant enzyme SOD activity increased. | ||||
| Keywords | ||||
| chronic hepatitis C; IL-10; pegylated interferon | ||||
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