Silica Nanoparticles as a Potential Carrier for Doxycycline Hyclate
Ashour, M., Soliman, I., Mabrouk, M., H. Behere, H., Tohamy, K. (2020). Silica Nanoparticles as a Potential Carrier for Doxycycline Hyclate. EKB Journal Management System, 21(1), 33-41. doi: 10.21608/ejbbe.2020.40105.1034
Mohamed M Ashour; Islam Soliman; Mostafa Mabrouk; Hanan H. Behere; Khairy Tohamy. "Silica Nanoparticles as a Potential Carrier for Doxycycline Hyclate". EKB Journal Management System, 21, 1, 2020, 33-41. doi: 10.21608/ejbbe.2020.40105.1034
Ashour, M., Soliman, I., Mabrouk, M., H. Behere, H., Tohamy, K. (2020). 'Silica Nanoparticles as a Potential Carrier for Doxycycline Hyclate', EKB Journal Management System, 21(1), pp. 33-41. doi: 10.21608/ejbbe.2020.40105.1034
Ashour, M., Soliman, I., Mabrouk, M., H. Behere, H., Tohamy, K. Silica Nanoparticles as a Potential Carrier for Doxycycline Hyclate. EKB Journal Management System, 2020; 21(1): 33-41. doi: 10.21608/ejbbe.2020.40105.1034

Silica Nanoparticles as a Potential Carrier for Doxycycline Hyclate

Egyptian Journal of Biomedical Engineering and Biophysics
Article 4, Volume 21, Issue 1, 2020, Page 33-41  XML PDF (1.58 MB)
Document Type: Original Article
DOI: 10.21608/ejbbe.2020.40105.1034
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Authors
Mohamed M Ashourorcid 1; Islam Soliman email orcid 2; Mostafa Mabrouk3; Hanan H. Behere4; Khairy Tohamyorcid 5
1Basic Sciences Department, Badr University in Cairo (BUC)
2Department of physics, faculty of Science, Al Azhar University, Cairo, Egypt.
3Refractories, Ceramics and Building materials Department, (Biomaterials group), National Research Centre, 33El Bohouth st.(former EL Tahrir st.)- Dokki- Giza- Egypt
4Refractories, Ceramics and Building materials Department, National Research Centre
5physics department,Faculty of Science, Al-Azhar University, Cairo, Egypt
Abstract
Abstract: Silica nanoparticles (SiO2 NPs) have found applications in many advanced biomedical fields. This research work is concerned with the preparation of amorphous silica nanoparticles by the hydrolysis of tetraethyl orthosilicate (TEOS) in ethanol medium and different surfactants such as cetyltrimethylammonium bromide (CTAB) and polyvinylpyrrolidone (PVP) and study the final properties of the prepared silica nanoparticles. The synthesized nanoparticles were systematically characterized by XRD, FTIR, particle size analysis and TEM. The XRD results revealed the crystallinity of silica nanoparticles. FTIR spectroscopy confirmed the presence of Si-O in the sample. The data obtained from DLS showed that particles with size of 198 nm had prepared. Moreover, the cytotoxicity of blanked silica NPs and Doxycycline Hyclate (DOX) loaded silica NPs on Human bone osteosarcoma cells (Saos-2) was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results approved that the fabricated Silica nano particles are biocompatible and have the potential to be a convenient drug carrier.
Keywords
Silica nanoparticles; Microemulsion synthesis; cytotoxicity; Doxycycline Hyclate
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