Angiotensin converting enzyme gene polymorphism in dyslipidemia and hypertension
Mohamed, N., Fawzy, L., Hasan, A. (2021). Angiotensin converting enzyme gene polymorphism in dyslipidemia and hypertension. EKB Journal Management System, 2(1), 30-36. doi: 10.21608/jram.2020.33184.1064
Nagham Mohamed; Laila Fawzy; Asmaa Hasan. "Angiotensin converting enzyme gene polymorphism in dyslipidemia and hypertension". EKB Journal Management System, 2, 1, 2021, 30-36. doi: 10.21608/jram.2020.33184.1064
Mohamed, N., Fawzy, L., Hasan, A. (2021). 'Angiotensin converting enzyme gene polymorphism in dyslipidemia and hypertension', EKB Journal Management System, 2(1), pp. 30-36. doi: 10.21608/jram.2020.33184.1064
Mohamed, N., Fawzy, L., Hasan, A. Angiotensin converting enzyme gene polymorphism in dyslipidemia and hypertension. EKB Journal Management System, 2021; 2(1): 30-36. doi: 10.21608/jram.2020.33184.1064

Angiotensin converting enzyme gene polymorphism in dyslipidemia and hypertension

Journal of Recent Advances in Medicine
Article 4, Volume 2, Issue 1, January 2021, Page 30-36  XML PDF (497.82 K)
Document Type: Original Article
DOI: 10.21608/jram.2020.33184.1064
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Authors
Nagham Mohamed email 1; Laila Fawzy2; Asmaa Hasan2
1Clinical Pathology Department , Student Hospital, Helwan University, Helwan, Egypt.
2Clinical Pathology Department, Faculty of Medicine for Girls, Cairo, Al-Azhar University, Egypt.
Abstract
ABSTRACT
Background: Hypertension and dyslipidemia have a multifactorial background based on genetic and environmental interactive factors. Increasing blood pressure (BP) and hypertension incidence have also been found to be linked with elevated blood lipids rates. Insertion/deletion (I/D) polymorphisms of the angiotensin converting enzyme (ACE) are said to be linked to pathogenesis of both hypertension and dyslipidemia.  
Objectives: to investigate the presence of the three genotypes of ACE gene (I/D) polymorphisms with hypertension and dyslipidemia.
Subjects and methods: Participants included 30 Egyptian patients with hypertension and /or dyslipidaemia (Group I) and 20 apparently healthy controls (Group II). For all participants, DNA was isolated and amplified by polymerase chain reaction (PCR); the product was recognized by gel electrophoresis according to their size.
Results: diferent ACE genotypes frequencies were detected according to the presence or absence of 287 bp fragment in intron 16; 30% for Deletion/Deletion  (DD), 56.7%  for Insertion/Deletion (ID) and 13.3% for  Insertion/Insertion (II) in patients group, denoting that (I) allele has a significant association with hypertension and dyslipidemia (p < 0.05).
Conclusions: There is increased frequency of ACE I/D and I/I, therefore, the I allele was common among Egyptian patients affected with hypertension and /or dyslipidaemia.
Keywords
Keywords: ACE; dyslipidaemia; Egypt; hypertension; polymorphism
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