Anti-Tumor Effect of Green Tea Extract, Simvastatin and Gamma Radiation on Solid Tumor in Mice
Abdelrahman, I., El-Kashef, H., Hassan, N. (2020). Anti-Tumor Effect of Green Tea Extract, Simvastatin and Gamma Radiation on Solid Tumor in Mice. EKB Journal Management System, 53(4), 39-52. doi: 10.21608/ajnsa.2020.22827.1322
Ibrahim Y. Abdelrahman; Hussein El-Kashef; Nagwa H.A. Hassan. "Anti-Tumor Effect of Green Tea Extract, Simvastatin and Gamma Radiation on Solid Tumor in Mice". EKB Journal Management System, 53, 4, 2020, 39-52. doi: 10.21608/ajnsa.2020.22827.1322
Abdelrahman, I., El-Kashef, H., Hassan, N. (2020). 'Anti-Tumor Effect of Green Tea Extract, Simvastatin and Gamma Radiation on Solid Tumor in Mice', EKB Journal Management System, 53(4), pp. 39-52. doi: 10.21608/ajnsa.2020.22827.1322
Abdelrahman, I., El-Kashef, H., Hassan, N. Anti-Tumor Effect of Green Tea Extract, Simvastatin and Gamma Radiation on Solid Tumor in Mice. EKB Journal Management System, 2020; 53(4): 39-52. doi: 10.21608/ajnsa.2020.22827.1322

Anti-Tumor Effect of Green Tea Extract, Simvastatin and Gamma Radiation on Solid Tumor in Mice

Arab Journal of Nuclear Sciences and Applications
Article 5, Volume 53, Issue 4, October 2020, Page 39-52  XML PDF (1.24 MB)
Document Type: Original Article
DOI: 10.21608/ajnsa.2020.22827.1322
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Authors
Ibrahim Y. Abdelrahman email orcid 1; Hussein El-Kashef2; Nagwa H.A. Hassan3
1Radiation Biology Department, National Center for Radiation Research and Technology
2Egyptian Atomic Energy Authority, National Center for radiation Research and technology, Radiation Biology Department
3Zoology department, Faculty of Science, Ain-Shams University
Abstract
The current study was conducted of six groups (n=12) to define the efficacy of epigallocatechin gallate, simvastatin and gamma radiation individually or combined together to reduce solid tumor size induced by intramuscular injection of EC cells in the right thigh of the targeted mice. Magnetic resonance imaging device 1.5 Tesla used for radiology imaging of the normal and ascites-bearing mice under anesthesia. The animals with solid tumor were followed up daily for recording deaths, tumor size, rate of inflammation and gangrene in the tumor area of hind limb. Magnetic resonance imaging showed the intraperitoneal ascites and the soft organs (liver, kidney and intestine) which were bright in the case of ascites-bearing mouse than the normal control. Triple therapy regimen significantly reduced the tumor size (662.6±12.5) compared to the positive control (825±21.8) and increased survival rate to 66.7% compared to 25% in the positive control. Triple therapy reduced the inflammation of tumor area, preventing the gangrene incidence, and showed the best value of T/C=142, ILS=42.11 and TIR %=19.6 compared to the positive control and single treatments, so it is considered as an anti-tumor regimen according to the National Cancer Institute criteria.
Keywords
Solid Tumor; Green Tea extract; Simvastatin; Gamma radiation; MRI; Combination Therapy
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