Efficacy of Hyaluronic Acid in the Treatment of MIA-induced Ankle Osteoarthritis in Rats and its Effect on Antioxidant Response Element
M. Halfaya, F., G.H., R., U., H., O.M., A., W., A. (2020). Efficacy of Hyaluronic Acid in the Treatment of MIA-induced Ankle Osteoarthritis in Rats and its Effect on Antioxidant Response Element. EKB Journal Management System, 27(2), 119-127. doi: 10.21608/jvmr.2020.34766.1020
Fatma M. Halfaya; Ragab G.H.; Hagag U.; Ahmed O.M.; Abou Elkheir W.. "Efficacy of Hyaluronic Acid in the Treatment of MIA-induced Ankle Osteoarthritis in Rats and its Effect on Antioxidant Response Element". EKB Journal Management System, 27, 2, 2020, 119-127. doi: 10.21608/jvmr.2020.34766.1020
M. Halfaya, F., G.H., R., U., H., O.M., A., W., A. (2020). 'Efficacy of Hyaluronic Acid in the Treatment of MIA-induced Ankle Osteoarthritis in Rats and its Effect on Antioxidant Response Element', EKB Journal Management System, 27(2), pp. 119-127. doi: 10.21608/jvmr.2020.34766.1020
M. Halfaya, F., G.H., R., U., H., O.M., A., W., A. Efficacy of Hyaluronic Acid in the Treatment of MIA-induced Ankle Osteoarthritis in Rats and its Effect on Antioxidant Response Element. EKB Journal Management System, 2020; 27(2): 119-127. doi: 10.21608/jvmr.2020.34766.1020

Efficacy of Hyaluronic Acid in the Treatment of MIA-induced Ankle Osteoarthritis in Rats and its Effect on Antioxidant Response Element

Journal of Veterinary Medical Research
Article 2, Volume 27, Issue 2, December 2020, Page 119-127  XML PDF (968.52 K)
Document Type: Original Article
DOI: 10.21608/jvmr.2020.34766.1020
View on SCiNiTO View on SCiNiTO
Authors
Fatma M. Halfaya email 1; Ragab G.H.1; Hagag U.1; Ahmed O.M.2; Abou Elkheir W.3
1Surgery, Anesthesiology and Radiology Department, Faculty of Veterinary Medicine, Beni Suef University, Egypt
2Physiology Division, Zoology Department, Faculty of Science, Egypt
3Department of Immunology, Military Medical Academy, Cairo, Egypt
Abstract
Ankle osteoarthritis (OA) is a long-standing inflammatory degeneration disease; until now, its pathogenesis remains ambiguous. There is no complete remedy from OA and the present pharmacological therapy choices are restrained and combined with undesirable side effects. Clinically, Hyaluronic acid (HA) is widely consumed to cure OA. The present experiment aimed to assess the role of HA in the remedy of experimentally Monosodium iodoacetate (MIA) -induced ankle OA in the rat model. Thirty male Wistar rats were divided into 3 groups (each of 10 rats). Rats of group I were injected with 1 mg MIA in the right ankle joint for two successive days, while those of group II were treated with saline instead of MIA; and group III( osteoarthritic + HA) rats were injected with HA in the ankle joint at 2nd, 3rd, and 4th weeks following injection of MIA. Bodyweight, ankle measurement, total leukocytes count (TLC), antioxidant response element (ARE) level, and joint Magnetic Resonance Imaging (MRI) were investigated. HA reduced expressions of joint ARE level. HA also markedly reduced the TLC. The administration of HA decreases ankle measurement in MIA-induced OA rats. MRI of HA showed a gradual reduction in joint damage. These results suggest that HA has improvement effects on OA rats which are assessed through anti-inflammatory and antioxidant effects.
Keywords
Ankle osteoarthritis; Antioxidant Response Element; Hyaluronic acid
Statistics
Article View: 488
PDF Download: 465