SYNTHESIS OF SOME NEW BENZOFURAN DERIVATIVES OF EXPECTED BIOLOGICAL ACTIVITY
HESSEIN, S. (2007). SYNTHESIS OF SOME NEW BENZOFURAN DERIVATIVES OF EXPECTED BIOLOGICAL ACTIVITY. EKB Journal Management System, 18(Issue 1-A), 103-114. doi: 10.21608/absb.2007.11106
S. A. HESSEIN. "SYNTHESIS OF SOME NEW BENZOFURAN DERIVATIVES OF EXPECTED BIOLOGICAL ACTIVITY". EKB Journal Management System, 18, Issue 1-A, 2007, 103-114. doi: 10.21608/absb.2007.11106
HESSEIN, S. (2007). 'SYNTHESIS OF SOME NEW BENZOFURAN DERIVATIVES OF EXPECTED BIOLOGICAL ACTIVITY', EKB Journal Management System, 18(Issue 1-A), pp. 103-114. doi: 10.21608/absb.2007.11106
HESSEIN, S. SYNTHESIS OF SOME NEW BENZOFURAN DERIVATIVES OF EXPECTED BIOLOGICAL ACTIVITY. EKB Journal Management System, 2007; 18(Issue 1-A): 103-114. doi: 10.21608/absb.2007.11106

SYNTHESIS OF SOME NEW BENZOFURAN DERIVATIVES OF EXPECTED BIOLOGICAL ACTIVITY

Al-Azhar Bulletin of Science
Article 15, Volume 18, Issue 1-A, June 2007, Page 103-114  XML PDF (379.59 K)
Document Type: Original Article
DOI: 10.21608/absb.2007.11106
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Author
S. A. HESSEIN*
Chemistry Department, Faculty of Science (Girl’s), Al-Azhar University, Cairo, Egypt
Abstract
Treatment of 1-[6-hydroxy-4-methoxybenzofuran-5-yl]ethanone (1) with cinnamaldehyde gave 1-[6-hydroxy-4-methoxybenzofuran-5-yl]-5-phenylpenta-2,4-diene-1-one (2) which reacted with formaline and 4-chloroniline to give benzofuran derivative (3) according to Mannich reaction. Interaction of 2 with 20% of sulphuric acid, malononitrile, ethylcyano acetate, phenyl hydrazine and guanidine hydrochloride afforded the corresponding furo[3,2-g]chromon-5-one (4), pyridine, pyrazole and pyrimidine derivatives  (5-8).  Also,  compound 8 reacted with phosphorus-oxychloride in dimethyl formamide and p-flurobenzylidenemalononitrile to give formyl and pyrimidopyrimidene derivatives (10, 12).
Keywords
BENZOFURAN DERIVATIVES; Biological Activity
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