PRELIMINARY STUDY ON THE EFFECT OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION ON NEGATIVE SYMPTOMS IN PATIENTS WITH SCHIZOPHRENIA
Nagy, N., El Ghoniemy, S., Kito, S., El Missiry, M., ElKholy, H., Yousry, S. (2019). PRELIMINARY STUDY ON THE EFFECT OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION ON NEGATIVE SYMPTOMS IN PATIENTS WITH SCHIZOPHRENIA. EKB Journal Management System, 70(4, 5 & 6), 307-314. doi: 10.21608/asmj.2019.111167
Nahla Nagy; Soheir El Ghoniemy; Shinsuke Kito; Marwa El Missiry; Hussien ElKholy; Shrief Yousry. "PRELIMINARY STUDY ON THE EFFECT OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION ON NEGATIVE SYMPTOMS IN PATIENTS WITH SCHIZOPHRENIA". EKB Journal Management System, 70, 4, 5 & 6, 2019, 307-314. doi: 10.21608/asmj.2019.111167
Nagy, N., El Ghoniemy, S., Kito, S., El Missiry, M., ElKholy, H., Yousry, S. (2019). 'PRELIMINARY STUDY ON THE EFFECT OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION ON NEGATIVE SYMPTOMS IN PATIENTS WITH SCHIZOPHRENIA', EKB Journal Management System, 70(4, 5 & 6), pp. 307-314. doi: 10.21608/asmj.2019.111167
Nagy, N., El Ghoniemy, S., Kito, S., El Missiry, M., ElKholy, H., Yousry, S. PRELIMINARY STUDY ON THE EFFECT OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION ON NEGATIVE SYMPTOMS IN PATIENTS WITH SCHIZOPHRENIA. EKB Journal Management System, 2019; 70(4, 5 & 6): 307-314. doi: 10.21608/asmj.2019.111167

PRELIMINARY STUDY ON THE EFFECT OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION ON NEGATIVE SYMPTOMS IN PATIENTS WITH SCHIZOPHRENIA

Ain Shams Medical Journal
Article 6, Volume 70, 4, 5 & 6, July 2019, Page 307-314  XML PDF (233.3 K)
Document Type: Original Article
DOI: 10.21608/asmj.2019.111167
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Authors
Nahla Nagy1; Soheir El Ghoniemy1; Shinsuke Kito2; Marwa El Missiry1; Hussien ElKholy1; Shrief Yousry1
1Department of Neurology and Psychiatry, Faculty of Medicine, Ain Shams University, Egypt.
2Department of Psychiatry and Advanced Medical Technology, Japan.
Abstract
Back Ground: Negative symptoms of schizophrenia have been demonstrated to be the most relevant predictor of increased future socio-occupational dysfunction and poorer quality of life which is linked to impaired functioning of the prefrontal cortex, mainly reduced activation of the dorsolateral prefrontal cortex. Repetitive Trans-cranial Magnetic Stimulation (rTMS) is a relatively safe and non-invasive tool to modulate neuronal activity. High-frequency rTMS might have role in improvement of negative symptoms of schizophrenia. Aim of work: The Aim of this study to explore the effects of high
frequency rTMS stimulation to the DLPFC on negative symptoms observed in schizophrenia patients. Patients and Methods: 40 patients with schizophrenia who accept and there guardians to participate in the study and sign the written informed consent were assessed by Positive and Negative Syndrome Scale for Schizophrenia (PANSS), before the rTMS sessions and after the sessions. Meanwhile the operator allocated the subjects to active or sham group then the subjects of the study received active or Sham rTMS . The rTMS was delivered for 3 sessions /week during six weeks, each session lasts for 13 minutes. Results: There was a statistical significance between active and sham group as regard PANSS Negative subdomain scale, used before and after the rTMS sessions (P value= 0.001 ) Also there was a statistical significant difference among active group before and after the rTMS stimulation( P value<0.001). Conclusion: This study suggests that high frequency rTMS applied to DLPFC may be of benefit in alleviating negative symptoms in schizophrenic patients. A larger sample size is needed to confirm our findings.
Keywords
Negative symptoms; schizophrenia; repetitive Trans Cranial Magnetic Stimulation (rTMS); Doros Lateral Prefrontal cortex (DLPFC); Electro convulsive Therapy (ECT) positive and negative syndrome scale (PANSS)
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