EVALUATION OF RAFTLIN MRNA IN HEPATOCELLULAR CARCINOMA | ||||
| Ain Shams Medical Journal | ||||
| Article 10, Volume 70, 4, 5 & 6, July 2019, Page 349-359 PDF (448.54 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/asmj.2019.111197 | ||||
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| Authors | ||||
| Mariam Sameh Boshra1; Mahmoud Shawky El Meteini2; Ayman El-Sayed Shafei3; Marwa Matboly4; Hebatalla Said Ali4 | ||||
| 1Medical Biochemistry and Molecular biology department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. | ||||
| 2Surgery department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. | ||||
| 3Biomedical Research Department, Armed Forces College of Medicine, Cairo, Egypt. | ||||
| 4Medical Biochemistry and Molecular biology department,Faculty of Medicine, Ain Shams University, Cairo, Egypt. | ||||
| Abstract | ||||
| Background: Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy of adults. It is the sixth most common cancer worldwide and the second most common cause of cancer death. More than 60% of patients are diagnosed with latestage disease after metastasis has occurred, resulting in an overall 5-year survival rate of < 16%. Aim of the work: To characterize new diagnostic marker for HCC that can help in early diagnosis. Patients and methods: 103 subjects were included in this study stratified into 3 groups, healthy controls, patients with HCC and patients with HCV. Serum and tissue samples were obtained. Bioinformatics analysis to retrieve mRNA relevant to HCC, real time PCR for determining the relative expression of RAFTLIN mRNA in sera and tissue samples. Results: There was statistically significant difference in the expression of RAFTLIN mRNA among patients with HCC compared with the other two groups. Conclusion: The results demonstrated the promising role of RAFTLIN mRNA as a novel marker for early detection of HCC. | ||||
| Keywords | ||||
| HCC; Hepatocellular carcinoma; mRNA | ||||
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