SYNTHESIS OF PYRAZINAMIDE DERIVATIVES AS LEUCONOSTOC MESENTEROIDES GROWTH INHIBITOR AND OTHER MICROORGANISMS
ABDELWAHAB, A., EL-HADDAD, A., EID, F., BEDAIR, A., ADAWY EL-DEEB, A., EL-SHERBENY, G. (2007). SYNTHESIS OF PYRAZINAMIDE DERIVATIVES AS LEUCONOSTOC MESENTEROIDES GROWTH INHIBITOR AND OTHER MICROORGANISMS. EKB Journal Management System, 18(Issue 2-A), 127-140. doi: 10.21608/absb.2007.11124
ASHRAF H. ABDELWAHAB; A. F. EL-HADDAD; F. A. EID; A. M. BEDAIR; A. M. ADAWY EL-DEEB; G. M. EL-SHERBENY. "SYNTHESIS OF PYRAZINAMIDE DERIVATIVES AS LEUCONOSTOC MESENTEROIDES GROWTH INHIBITOR AND OTHER MICROORGANISMS". EKB Journal Management System, 18, Issue 2-A, 2007, 127-140. doi: 10.21608/absb.2007.11124
ABDELWAHAB, A., EL-HADDAD, A., EID, F., BEDAIR, A., ADAWY EL-DEEB, A., EL-SHERBENY, G. (2007). 'SYNTHESIS OF PYRAZINAMIDE DERIVATIVES AS LEUCONOSTOC MESENTEROIDES GROWTH INHIBITOR AND OTHER MICROORGANISMS', EKB Journal Management System, 18(Issue 2-A), pp. 127-140. doi: 10.21608/absb.2007.11124
ABDELWAHAB, A., EL-HADDAD, A., EID, F., BEDAIR, A., ADAWY EL-DEEB, A., EL-SHERBENY, G. SYNTHESIS OF PYRAZINAMIDE DERIVATIVES AS LEUCONOSTOC MESENTEROIDES GROWTH INHIBITOR AND OTHER MICROORGANISMS. EKB Journal Management System, 2007; 18(Issue 2-A): 127-140. doi: 10.21608/absb.2007.11124

SYNTHESIS OF PYRAZINAMIDE DERIVATIVES AS LEUCONOSTOC MESENTEROIDES GROWTH INHIBITOR AND OTHER MICROORGANISMS

Al-Azhar Bulletin of Science
Article 9, Volume 18, Issue 2-A, December 2007, Page 127-140  XML PDF (286.39 K)
Document Type: Original Article
DOI: 10.21608/absb.2007.11124
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Authors
ASHRAF H. ABDELWAHAB* 1; A. F. EL-HADDAD1; F. A. EID1; A. M. BEDAIR1; A. M. ADAWY EL-DEEB2; G. M. EL-SHERBENY3
1Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt.
2Department of Research abd Development Affair Sugar & Integrated Industries Companies, EL-Hwamdia, Giza
3Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt.
Abstract
Synthesis and reactions of  4-pyrazine-2-carboxamido carboxylic acid derivatives 3a-c were studied. Various N-[4-(5-oxo-oxazol-2-yl)-phenyl]pyrazine-2-carboxamides 7-11 were obtained via condensation of 3c with different chemical reagents. Interaction of 10b,c with p-toludine and/or hydrazine hydrate afforded the corresponding N-[4-(1H-imidazol-2-yl)phenyl]pyrazine-2-carboxamides 12a,b respectively. Antimicrobial screening showed that 3c possess a promising effect against the growth of Leuconostoc sp. and other tested Gram-positive, Gram-negative and fungi.
Thestructures of the newly derivatives were confirmed by IR, 1H NMR, 13C NMR and mass spectra studies.
Keywords
4-pyrazine-2-carboxamido carboxylic acid derivatives; N-[4-(5-oxo-oxazol-2-yl)phenyl]pyrazine-2-carboxamides; N-[4-(1H-imidazol-2-yl)phenyl]pyrazine-2-carbox-amides; 1,2,4-triazine-6-one derivatives; Leuconostoc sp. Growth inhibitor
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