COMPARATIVE STUDY BETWEEN VAGINAL NATURAL PROGESTERONE AND ORAL DYDROGESTERONE IN PREVENTION OF RED DEGENERATION OF UTERINE FIBROID IN PREGNANCY
Karkour, T., Abdeldaiem, T., Hefila, N., Elghareeb, S. (2020). COMPARATIVE STUDY BETWEEN VAGINAL NATURAL PROGESTERONE AND ORAL DYDROGESTERONE IN PREVENTION OF RED DEGENERATION OF UTERINE FIBROID IN PREGNANCY. EKB Journal Management System, 10(3), 216-222. doi: 10.21608/ebwhj.2020.34910.1100
Tarek A. Karkour; Tamer M. Abdeldaiem; Nirmeen Hefila; Sarah M. Elghareeb. "COMPARATIVE STUDY BETWEEN VAGINAL NATURAL PROGESTERONE AND ORAL DYDROGESTERONE IN PREVENTION OF RED DEGENERATION OF UTERINE FIBROID IN PREGNANCY". EKB Journal Management System, 10, 3, 2020, 216-222. doi: 10.21608/ebwhj.2020.34910.1100
Karkour, T., Abdeldaiem, T., Hefila, N., Elghareeb, S. (2020). 'COMPARATIVE STUDY BETWEEN VAGINAL NATURAL PROGESTERONE AND ORAL DYDROGESTERONE IN PREVENTION OF RED DEGENERATION OF UTERINE FIBROID IN PREGNANCY', EKB Journal Management System, 10(3), pp. 216-222. doi: 10.21608/ebwhj.2020.34910.1100
Karkour, T., Abdeldaiem, T., Hefila, N., Elghareeb, S. COMPARATIVE STUDY BETWEEN VAGINAL NATURAL PROGESTERONE AND ORAL DYDROGESTERONE IN PREVENTION OF RED DEGENERATION OF UTERINE FIBROID IN PREGNANCY. EKB Journal Management System, 2020; 10(3): 216-222. doi: 10.21608/ebwhj.2020.34910.1100

COMPARATIVE STUDY BETWEEN VAGINAL NATURAL PROGESTERONE AND ORAL DYDROGESTERONE IN PREVENTION OF RED DEGENERATION OF UTERINE FIBROID IN PREGNANCY

Evidence Based Women's Health Journal
Article 5, Volume 10, Issue 3, September 2020, Page 216-222  XML PDF (1021.88 K)
Document Type: Original Article
DOI: 10.21608/ebwhj.2020.34910.1100
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Authors
Tarek A. Karkour1; Tamer M. Abdeldaiem1; Nirmeen Hefila email 2; Sarah M. Elghareeb1
1Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Egypt
2Obstatrics and gynecology at Alexandria faculty of medicine university maternity hospital Elshatby maternity hospital. Egypt
Abstract
Background: Uterine leiomyomas are highly prevalent benign monoclonal tumors, arising from the smooth muscle of the myometrium; they occur in up to 50-60% of reproductive age women, causing significant morbidity in up to 30% of women. The most serious complication of uterine fibroids; is red degeneration that causes severe pain, and may lead to preterm labour, miscarriage, fetal and maternal morbidity and mortality.
Aim: This work was designed to compare between the effect of vaginal natural MP and oral dydrogesterone in prevention of red degeneration of uterine fibroid during pregnancy.
Materials and Methods: Patients were recruited from El-Shatby Maternity University Hospital. They were 50 pregnant females, diagnosed having a uterine fibroid more than 3 cm in size then there were divided into two groups ; group A included twenty-five treated by vaginal natural progesterone, group B included twenty-five treated by oral dydrogesterone. All patients at 14-15 weeks of gestational age underwent complete history taking, clinical examination and ultrasound examination for mean gestational age and assessment of the type and uterine fibroid.
Results: The results showed that there were no statistical significant differences as regards age, obstetric history (gravidity and parity), number, site, grade and size of the fibroid. There was a significant difference between the two studied groups regarding the acute abdominal pain, it occurred to only 3 cases (12%) in group A, versus 16 cases (64%) in group B. Regarding occurrence of red degeneration, it occurred only to 3 cases (12%) in group A, while in group B it occurred to 15 cases (60%).
Keywords
Oral dydrogesterone; pregnancy; red degeneration of uterine fibroid; vaginal natural progesterone
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