Efficient Synthesis of Biopertinent Dihydropyrimidine (thi) one Derivatives via Three-component One-pot Synthesis Catalyzed by Tetrachlorosilane | ||
| Egyptian Journal of Chemistry | ||
| Article 3, Volume 56, Issue 4, August 2013, Pages 291-305 PDF (501.2 K) | ||
| DOI: 10.21608/ejchem.2013.1114 | ||
| Abstract | ||
| SERIES of dihydropyrimidine(thi)one derivatives were prepared, in …..good yields at room temperature by using a modified Biginelli reaction. The products were obtained through a one-pot three-component coupling of β-diketones, aldehydes and urea (or thiourea) in the presence of a catalytic amount of tetrachlorosilane (TCS). The effect of catalyst type, molar ratios of reactants and solvent type were also investigated; best results were obtained when TCS was employed as a catalyst and CH2Cl2 as a solvent at room temperature. | ||
| Keywords | ||
| Three-component; Dihydropyrimidinones; Biginelli reaction and Tetrachlorosilane | ||
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