Prognostic Value of Platelet to Lymphocyte Ratio in Patients with Non-Small Cell Lung Cancer | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 25, Volume 72, Issue 9, July 2018, Page 5298-5303 PDF (415.38 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2018.11166 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mohammad Sabry Elkady; Ghada Refaat; Zeinab Elsayed; Kyrillus Farag 
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| Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: The prognostic value of Platelet-to-lymphocyte ratio (PLR) in patients with non-small-cell lung cancer (NSCLC) is still indistinct. We conducted this study to assess the prognostic significance of pretreatment PLR in patients with unresectable NSCLC. Aim of the Work: to assess the prognostic significance of pre-treatment PLR in patients with NSCLC. Material and Methods: we retrospectively reviewed 130 patients treated for NSCLC with definitive/palliative chemotherapy and/or radiotherapy in Ain-Shams University hospital, Clinical Oncology department between January 2014 and December 2016. Pre-treatment CBC was available for the 130 patients to calculate PLR by dividing the absolute platelet count by the absolute lymphocytic count. Results: Out of 130 patients with available pre-treatment complete blood picture, population age ranged from 23 to 87 years. Male to female ratio was 4.8:1. Adenocarcinoma presents 51% of cases. Unresectable stage II and stage III present 2% and 27% respectively, while Stage IV presents 69%. Using a cut-off value of 150, high PLR>150 was significantly associated with poor overall survival (OS) (median OS: 10.33 months; 95% CI: 6.23-14.42), compared to patients with PLR<150; (median OS: 24.63 months, 95% CI: 11.5-37.76, p=0.008), but not PFS. In multivariate analysis, PLR>150 was an independent poor prognostic factor for OS; (HR=1.9, 95% CI; 1.092-3.3, p=0.023). Conclusion: High PLR is associated with poor OS in patients with unresectable NSCLC. | ||||
| Keywords | ||||
| Platelet to Lymphocyte ratio; Non-Small Cell Lung Cancer; prognostic factor | ||||
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