Toxic effect of combined treatment with cadmium and piroxicam on liver and kidney tissues | ||||
| Benha Veterinary Medical Journal | ||||
| Article 30, Volume 36, Issue 1, March 2019, Page 272-279 PDF (449.79 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bvmj.2019.111734 | ||||
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| Authors | ||||
| Omayma Abo-Zaid1; Hussein Abdelmaksoud1; Ahmed Abdeen2 | ||||
| 1Department of Biochemistry and Clinical Biochemistry, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt. | ||||
| 2Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt. | ||||
| Abstract | ||||
| Cadmium (Cd) is a well-known hazardous environmental contaminant. Non-steroidal anti-inflammatory drugs (NSAIDs) have been reported to have a deleterious effect on liver and kidney. Therefore, in this study, we investigated whether NSAIDS could potentiate the toxic effect of Cd on liver and kidney. Twenty male Wister rats were divided randomly into 4 groups. Group 1:the control was injected saline daily. Group 2: received cadmium (5mg/kg) daily. Group 3: served as piroxicam were injected a single dose (10 mg/kg, i.p.). Group 4: received both Cd+Px. After 14 days, all rats were euthanized and blood samples, stomach, liver, and kidney tissues were collected. Treatment with Cd or Px alone significantly increased the liver and kidney function markers. However, when Cd and Px were given in a combination, Px potentiated the Cd-induced cellular damage in liver and kidney when compared to their individual treatment in liver and kidney functions and histopathological examination. Their combination could also enhance the apoptosis. | ||||
| Keywords | ||||
| Cd; Non-steroidal anti-inflammatory drugs; Piroxicam; liver damage; Renal damage | ||||
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