Evaluation of some hepatoprotective preparations in experimentally induced hepatopathy in Baladi goats | ||||
| Benha Veterinary Medical Journal | ||||
| Article 4, Volume 38, Issue 2, September 2020, Page 17-25 PDF (733.32 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bvmj.2020.26506.1194 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Rania Emam  1; Mohamed Ghanem 2; Yassen Abdel-Raoof3; Heba Elkhyat4
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| 1internal medicine,benha university | ||||
| 2Dept animal medicine Faculty vet Medicine.. Benha University | ||||
| 3internal medicine,benha univeresity | ||||
| 4internal medicine depatment | ||||
| Abstract | ||||
| This work aimed to evaluate the hepatoprotective effect of garlic oil extract and artichoke extract with regarding to clinical, hematobiochemical alteration and oxidative stress status of induced acute hepatopathy in Baladi goats. Fifteen Baladi goats were kept for experimental induction of hepatopathy that treated orally with 0.3 ml /kg of carbon tetrachloride (CCL4)once and divided randomly into 3 groups each of five. Group A was kept as control positive. Group B and Group C were treated by garlic oil extract in dose 0.8mg/kg and artichoke extract in dose 10mg/kg for 15 days for hepatic protection before induction. Clinical and hematobiochemical examination were carried out at 1st, 3rd and 7th day after induction. Clinical examinations of CCl4 treated group at first day showed dullness, inappetence, pale mucous membranes, elevated body temperature and pulse rate and nervous manifestations. While garlic extract and artichoke extract l treated groups showed less severe clinical signs that began to disappear at 3rd day after induction. Hematobiochemical examination: induced acute hepatopathy group showed significant (P<0.05) decrease in RBCs, Hb, PCV, GPX and SOD and significant (P<0.05) increase in WBCs, ALT, AST, GGT, total and direct bilirubin, blood urea nitrogen, creatinine and MDA. While garlic extract and artichoke extract treated groups showed significant (P<0.05) increase in RBCs, Hb, PCV and antioxidant status with significant (P<0.05) decrease in liver damage indices of treated animals. Therefore, we concluded that garlic oil extract and artichoke extract could be used as hepatoprotective agent in Baladi goats. | ||||
| Keywords | ||||
| induced hepatopathy; garlic oil; artichok extract; Baladi goats | ||||
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