Evaluation of formaldehyde and binary ethylenimine inactivated Newcastle Disease Virus Vaccine from new isolate compared with imported NDV vaccine
Eladawy, S., El-Bagoury, G., El-Habbaa, A., El-Mahdy, S. (2020). Evaluation of formaldehyde and binary ethylenimine inactivated Newcastle Disease Virus Vaccine from new isolate compared with imported NDV vaccine. EKB Journal Management System, 38(2), 34-40. doi: 10.21608/bvmj.2020.21635.1148
Samar Fathi Eladawy; Gabr El-Bagoury; ayman said El-Habbaa; sausan El-Mahdy. "Evaluation of formaldehyde and binary ethylenimine inactivated Newcastle Disease Virus Vaccine from new isolate compared with imported NDV vaccine". EKB Journal Management System, 38, 2, 2020, 34-40. doi: 10.21608/bvmj.2020.21635.1148
Eladawy, S., El-Bagoury, G., El-Habbaa, A., El-Mahdy, S. (2020). 'Evaluation of formaldehyde and binary ethylenimine inactivated Newcastle Disease Virus Vaccine from new isolate compared with imported NDV vaccine', EKB Journal Management System, 38(2), pp. 34-40. doi: 10.21608/bvmj.2020.21635.1148
Eladawy, S., El-Bagoury, G., El-Habbaa, A., El-Mahdy, S. Evaluation of formaldehyde and binary ethylenimine inactivated Newcastle Disease Virus Vaccine from new isolate compared with imported NDV vaccine. EKB Journal Management System, 2020; 38(2): 34-40. doi: 10.21608/bvmj.2020.21635.1148

Evaluation of formaldehyde and binary ethylenimine inactivated Newcastle Disease Virus Vaccine from new isolate compared with imported NDV vaccine

Benha Veterinary Medical Journal
Article 7, Volume 38, Issue 2, September 2020, Page 34-40  XML PDF (172.64 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2020.21635.1148
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Authors
Samar Fathi Eladawy email 1; Gabr El-Bagoury2; ayman said El-Habbaaorcid 3; sausan El-Mahdy4
1live viral vaccines for poultry diseases, CLEVB,Abbasia Cairo
2virology veterinary medicine Benha university
3Department of Virology, Faculty of Veterinary Medicine, Benha University
4poultry diseases and Techniqual manager, CLEVB, Abbasia, Cairo
Abstract
Even massive vaccination programs, the incidence of Newcastle Disease virus (NDV) outbreaks in Egypt is still frequent with appearing new isolates that need production of new vaccines. In this study, NDV vaccine was prepared by using a new local isolate (NDV/Ch/Giza2014) inactivated by two different chemicals binary ethylenimine (BEI) and formaldehyde. The formaldehyde inactivated NDV (NDVF), BEI inactivated NDV (NDVEI) and imported inactivated Newcastle Disease virus (NDVI) vaccines were examined for generating humoral immune response in different groups of specific pathogen free (SPF) chicks. Vaccinated Chicks by NDVEI vaccine gave higher serum antibody titers than NDVF and NDVI Vaccines using Haemagglutination Inhibition (HI) test. The prepared and imported vaccines gave near percentage of protection against the local and the classical strain in chicks. It could be concluded that the locally prepared inactivated NDV vaccines can protect chicken against either homologous or heterologous challenging viruses and the NDVEI Vaccine gave higher protection percentage than NDVF and NDVI Vaccines.
Keywords
NDV; inactivated vaccine; binary ethylenimine; formaldehyde
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