Efficacy and safety of Tenofovir Disoproxil Fumarate in Patients with Chronic Hepatitis B with High Baseline Viral Load
Ahmed, A., Ghweil, A., Mahmoud, H. (2020). Efficacy and safety of Tenofovir Disoproxil Fumarate in Patients with Chronic Hepatitis B with High Baseline Viral Load. EKB Journal Management System, 3(2), 26-33. doi: 10.21608/svuijm.2020.111898
Ahmed Gad Mohamed Ahmed; Ali Abdel Rahman Sayed Ghweil; Hasan Sedeek Mahmoud. "Efficacy and safety of Tenofovir Disoproxil Fumarate in Patients with Chronic Hepatitis B with High Baseline Viral Load". EKB Journal Management System, 3, 2, 2020, 26-33. doi: 10.21608/svuijm.2020.111898
Ahmed, A., Ghweil, A., Mahmoud, H. (2020). 'Efficacy and safety of Tenofovir Disoproxil Fumarate in Patients with Chronic Hepatitis B with High Baseline Viral Load', EKB Journal Management System, 3(2), pp. 26-33. doi: 10.21608/svuijm.2020.111898
Ahmed, A., Ghweil, A., Mahmoud, H. Efficacy and safety of Tenofovir Disoproxil Fumarate in Patients with Chronic Hepatitis B with High Baseline Viral Load. EKB Journal Management System, 2020; 3(2): 26-33. doi: 10.21608/svuijm.2020.111898

Efficacy and safety of Tenofovir Disoproxil Fumarate in Patients with Chronic Hepatitis B with High Baseline Viral Load

SVU-International Journal of Medical Sciences
Article 6, Volume 3, Issue 2, July 2020, Page 26-33  XML PDF (270.39 K)
Document Type: Original research articles
DOI: 10.21608/svuijm.2020.111898
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Authors
Ahmed Gad Mohamed Ahmed* 1; Ali Abdel Rahman Sayed Ghweil2; Hasan Sedeek Mahmoudorcid 3
1Tropical Medicine and Gastroenterology Department, Faculty of Medicine, South Valley University,Qena
2Tropical Medicine and Gastroenterology Department, Faculty of Medicine, south valley University, Qena.
3Tropical Medicine and Gastroenterology Department, Faculty of Medicine, southvalleyUniversity,Qena
Abstract
Background: Chronic hepatitis B virus infection is an important cause of morbidity and mortality. Tenofovir disoproxil fumarate was licensed for the treatment of hepatitis B virus infection. So, the current study aimed to Evaluate efficacy and outcome of Tenofovir Disoproxil Fumarate in patients with Chronic Hepatitis B with High Baseline Viral Load. Patients and methods:One hundred Chronic HBV patients attend Outpatient Clinic of HBV treatment unit, Qena fever hospital, Qena, Egyptwere enrolled in this study and treated with Tenofovir Disoproxil Fumarate (300mg/day) for 24 weeks. Patients categorized into two groups: Group A: included 50 chronic HBV patients with Low Viral load < 1 million/ml and Group B: included 50 chronic HBV patients with High Viral load ≥ 1 million/ml.virological and biochemical response, as well as safety outcomes were assessed after 24 weeks of treatment. Results:The mean age of patients was 38.4 years and 33.9 years in Group A and Group B respectively. Number of males was 32 (64%) and 36 (72%) in Group A and Group B respectively. HBeAg was positive in 20 % and 36 % in Group A and Group B respectively. The rates of complete virological suppression were 88% in group A and 72% in group B. All patients achevied normalization of ALT. No severe adverse events were reported during the present study. No elevations in creatinine level were detected. Conclusion: Tenofovir Disoproxil Fumarate is an efficacious, safe and well-tolerated treatment in an Egyptian patient.
Keywords
Tenofovir; HBV; ALT
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