Anti-Müllerian hormone for prediction of ovarian stimulation response in polycystic ovary syndrome
Ali, K., Abdel-Rahman, M., Abdel-Ghany, M., Fayed, H., Taha, S. (2021). Anti-Müllerian hormone for prediction of ovarian stimulation response in polycystic ovary syndrome. EKB Journal Management System, 4(1), 13-21. doi: 10.21608/svuijm.2021.111999
Kamel M. Ali; Mohammad Abdel-Rahman; Mohammed F. Abdel-Ghany; Hanan M. Fayed; Sayed A. Taha. "Anti-Müllerian hormone for prediction of ovarian stimulation response in polycystic ovary syndrome". EKB Journal Management System, 4, 1, 2021, 13-21. doi: 10.21608/svuijm.2021.111999
Ali, K., Abdel-Rahman, M., Abdel-Ghany, M., Fayed, H., Taha, S. (2021). 'Anti-Müllerian hormone for prediction of ovarian stimulation response in polycystic ovary syndrome', EKB Journal Management System, 4(1), pp. 13-21. doi: 10.21608/svuijm.2021.111999
Ali, K., Abdel-Rahman, M., Abdel-Ghany, M., Fayed, H., Taha, S. Anti-Müllerian hormone for prediction of ovarian stimulation response in polycystic ovary syndrome. EKB Journal Management System, 2021; 4(1): 13-21. doi: 10.21608/svuijm.2021.111999

Anti-Müllerian hormone for prediction of ovarian stimulation response in polycystic ovary syndrome

SVU-International Journal of Medical Sciences
Article 4, Volume 4, Issue 1, January 2021, Page 13-21  XML PDF (451.33 K)
Document Type: Original research articles
DOI: 10.21608/svuijm.2021.111999
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Authors
Kamel M. Ali* 1; Mohammad Abdel-Rahman1; Mohammed F. Abdel-Ghany1; Hanan M. Fayed2; Sayed A. Taha1
1Obstetrics and GynecologyDepartment , Qena Faculty of Medicine, South Valley University
2Clinical and Chemical Pathology Department, Qena Faculty of Medicine, South Valley University
Abstract
Background: Women with polycystic ovarian syndrome (PCOS) are known to have elevated circulating Anti-Müllerian hormone (AMH), which has been found to desensitize ovarian follicles to follicle stimulating hormone (FSH).
Objectives: To determine the predictive value of serum anti-müllerian hormone (AMH) concentration on ovarian response to different stimulation protocols in polycystic ovary syndrome (PCOS).
Patients and Methods: A prospective comparative study was done in Obstetrics and Gynecology department, Qena Faculty of Medicine, South Valley University on 180 infertile women with PCOS attended the infertility outpatient clinic divided into three groups 60 patients each, the 1st group received clomiphene citrate, 2nd group received gonadotrophin, and the 3rd group offered Laparoscopic ovarian drilling, Ovulation and pregnancy rates were measured.
Results: in patients with PCO AMH level with a cutoff value of (3.8 ng/ml), could be used to predict response to CC in obese women, AMH levels of a cutoff value of (4.95 ng/ml), could be used to predict response to Gonadotrophin in women with PCOS, And an AMH level of a cutoff value of (5.74 ng/ml), could be used to predict response to laparoscopic ovarian diathermy in PCOS, there was a statistically significant relation between AMH level and Ovulation and pregnancy rates.
Conclusion: PCOS women with high serum AMH levels seem to be resistant to ovulation induction by clomiphen citrate, gonadotrophin and laparscopic ovarian drilling. Pretreatment measurement of serum AMH concentrations may therefore be a valuable predictor of success and may help in determining the starting dose.
Keywords
Anti-Müllerian hormone; ovarian stimulation response; polycystic ovary syndrome
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