Immunohistochemical Expression of E-cadherin in Invasive Duct Carcinoma of the Breast | ||||
| SVU-International Journal of Medical Sciences | ||||
| Article 16, Volume 4, Issue 1, January 2021, Page 112-120 PDF (543.97 K) | ||||
| Document Type: Original research articles | ||||
| DOI: 10.21608/svuijm.2021.112059 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Hala S. E Alaa Edin* 1; Seham A. R Ismail1; Ghada S. Osman1; Mohamed M. Wahman2; Eman M. S. Muhammad3 | ||||
| 1Pathology Departments, South Valley University, Egypt | ||||
| 2Oncology Departments, South Valley University, Egypt | ||||
| 3Pathology Departments, Sohag University, Egypt | ||||
| Abstract | ||||
| Breast cancer is the most frequent malignant tumor in women worldwide. E-Cadherin is a calcium-dependent epithelial cell adhesion molecule that is expressed at adherens junctions. Its loss may result in a poorly differentiated tumorphenotype. Cells with mutated E-cadherin demonstrate increased motility, altered organization of their actin cytoskeletonand associated with metastases, thereby providing evidence for its role as an invasion suppressor. Objectives: Assess the prognostic value of E-cadherin expression in invasive duct carcinoma (IDC) of the breastand to evaluate its correlations with other prognostic parameters. Materials and Methods: Immunohistochemical (IHC) E-Cadherin expression was studied in 60 IDC and the results were correlated with the clinico-pathological parameters. Results: E-cadherin was positive in 46/60 (76.7%) of IDC; 15/60 (25%) showed strong membranous staining. A significant inverse correlation was found between E-cadherin expression and number of lymph node metastasis. Conclusions: Loss of E-cadherin expression is a predictive of invasion and metastasis in IDC. | ||||
| Keywords | ||||
| Breast cancer; invasive duct carcinoma; E-Cadherin | ||||
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