A comparative study between the therapeutic role of bone marrow mesenchymal stem cells and that of histamine2 receptor antagonists (nizatidine) in the management of ibuprofen induced gastric ulcer in adult albino rats
Ahmed, O., Shalaby, S., Ibraheem, E., Metwally, A., Manawy, S. (2020). A comparative study between the therapeutic role of bone marrow mesenchymal stem cells and that of histamine2 receptor antagonists (nizatidine) in the management of ibuprofen induced gastric ulcer in adult albino rats. EKB Journal Management System, 37(3), 678-690. doi: 10.21608/bmfj.2020.112176
Osama Ahmed; Saadia Shalaby; Essam Ibraheem; Amal Metwally; Samia Manawy. "A comparative study between the therapeutic role of bone marrow mesenchymal stem cells and that of histamine2 receptor antagonists (nizatidine) in the management of ibuprofen induced gastric ulcer in adult albino rats". EKB Journal Management System, 37, 3, 2020, 678-690. doi: 10.21608/bmfj.2020.112176
Ahmed, O., Shalaby, S., Ibraheem, E., Metwally, A., Manawy, S. (2020). 'A comparative study between the therapeutic role of bone marrow mesenchymal stem cells and that of histamine2 receptor antagonists (nizatidine) in the management of ibuprofen induced gastric ulcer in adult albino rats', EKB Journal Management System, 37(3), pp. 678-690. doi: 10.21608/bmfj.2020.112176
Ahmed, O., Shalaby, S., Ibraheem, E., Metwally, A., Manawy, S. A comparative study between the therapeutic role of bone marrow mesenchymal stem cells and that of histamine2 receptor antagonists (nizatidine) in the management of ibuprofen induced gastric ulcer in adult albino rats. EKB Journal Management System, 2020; 37(3): 678-690. doi: 10.21608/bmfj.2020.112176

A comparative study between the therapeutic role of bone marrow mesenchymal stem cells and that of histamine2 receptor antagonists (nizatidine) in the management of ibuprofen induced gastric ulcer in adult albino rats

Benha Medical Journal
Article 18, Volume 37, Issue 3, September 2020, Page 678-690  XML PDF (2.09 MB)
Document Type: Original Article
DOI: 10.21608/bmfj.2020.112176
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Authors
Osama Ahmed; Saadia Shalaby; Essam Ibraheem; Amal Metwally; Samia Manawy
Department of Anatomy and embryology, Benha faculty of medicine, Benha University, Egypt
Abstract
Introduction: One of the widely used gastro protective agents are H2 receptor antagonists (H2RAs). But these drugs may induce several adverse effects. Recent studies have shown that mesenchymal stem cells (MSCs) play an important role in the healing of gut injuries.  Aim of the work: To evaluate the role of bone marrow- mesenchymal stem cells (BM- MSCs) in the treatment of gastric ulcer, and to compare their efficacy with H2RAs therapy.  Methods: 10 out of the 50 adult albino rats used in this study served as donors for stem cells and the other 40 rats were divided into four groups: Group I (control group). Group II (Gastric ulcer group < /em>), rats received 200mg /kg ibuprofen suspended in CMC-Na 1% given orally by gastric tube. Group III (Nizatidine treated group), rats with gastric ulcer were treated with 31.25 mg/kg nizatidine, given orally by gastric tube. Group IV (BM-MSCs treated group < /em>), rats with gastric ulcer were injected with BMMSCs in the rat tail vein.  Results: MSCs-treated group revealed improvement of histological structure and restoration of the normal architecture of the gastric mucosa. Nizatidine-treated group demonstrated nearly similar results to that of MSCs treated group. A significant decrease of tumor necrosis factor α (TNF-α) expression was observed in MSCs-treated group as well as nizatidine-treated group when compared to ulcer group (P<0.01).  Conclusion: MSCs could be a safer alternative therapy than H2RAs, with the benefit of avoiding the side effects of these drugs.
Keywords
BMMSCs; gastric ulcer; H2RAs; TNF-α
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