Effect of N-Acetylcysteine on Total Oxidant Status in Children With β-Thalassemia Major | ||||
| Medicine Updates | ||||
| Article 15, Volume 3, Issue 3, October 2020, Page 84-96 PDF (609 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/muj.2020.41090.1023 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Amany Khail  1; Mohamed H. Meabed2; Yasmeen A. Mohamed3; Rehab M. Abd-Elkareem4
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| 1Bani-sauf University | ||||
| 2Professor of Pediatrics, Faculty of Medicine | ||||
| 3assistant Professor of Pediatrics, Faculty of Medicine | ||||
| 4assistant professor of chemical and clinical pathology, faculty of medicine | ||||
| Abstract | ||||
| β-Thalassemias are due to β-globin gene mutation leading to the absence or reduction of β-globin chains formation. Numerous studies are showing the rising of oxidative stress in β-thalassemia major patients. The study aims to evaluate the effects of N-acetylcysteine (NAC) on total oxidant status and Hb levels in children with β-thalassemia major. This study is a randomized clinical trial in the department of pediatrics, Beni-Suef University during the period between May 2019 and October 2019. The subjects of the study were beta-thalassemia major, the study was conducted on 44 patients that were divided into two groups, 22 patients took NAC at a dose of 10 mg/kg (solvymist syrup or, NAC sachet) orally, for 3 months, and the second group as a non-treatment group. Article results show a significant increase in HB for the treatment group between form the first measurement until the 3rd month. There was a significant decrease between Total Oxidant Status before and after three months in the treatment group. Therefore, NAC may be effective in reducing serum Total oxidant status and increase pre-transfusion Hb levels in children with β-thalassemia major. | ||||
| Keywords | ||||
| TOS; Acetylcysteine; Β-Thalassemia; Oxidant | ||||
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