Evaluation of the molecular marker TOX protein in diagnosis of early stages of mycosis fungoides | ||||
Journal of Recent Advances in Medicine | ||||
Article 1, Volume 1, Issue 2, July 2020, Page 46-54 PDF (7.14 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/jram.2020.19493.1018. | ||||
View on SCiNiTO | ||||
Authors | ||||
Fatma Shabaka1; Nafissa Al Badawy2; Hanan Darwish3; Basem Salah 4 | ||||
1Dermatology and Venerology Department, Faculty of Medicine for girls, Cairo, Al- Azhar University, Egypt. | ||||
2Pathology Department, Faculty of Medicine Ain shams university, Cairo, Egypt. | ||||
3Dermatology and Venerology Department, Faculty of Medicine for girls, Cairo, Al- Azhar University, Egypt. | ||||
4Dermatology and venerology Department, nuclear martial authority, Cairo,Egypt. | ||||
Abstract | ||||
Background: Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma (CTCL). Differentiation of MF especially early stages (eMF) from its benign mimickers is important to ensure proper management. TOX is a critical regulator of early T-cell development in the thymus that is considered as a useful marker for MF diagnosis and prognosis. Objective: The aim of the current study was to evaluate the ability of molecular marker TOX protein in diagnosis of eMF, and its ability to differentiate eMF from similar benign inflammatory skin diseases (BIDs). Methodology: This is a case control study and was carried out on 60 subjects; 20 patients as eMF, 20 patients as (BIDs) and 20 normal skin specimens as control cases. The diagnosis was established after clinicopathological correlation. Immunohistochemistry (IHC) was done for MF, BIDs and normal skin cases for TOX and CD4 IHC stains. Results: TOX expression showed a significant positive expression in MF cases compared to BIDs and control groups, with 100% sensitivity and 95% specificity. The pattern of TOX IHC stain in MF was diffuse, while in BIDs was focal. Conclusion: TOX might be considered a diagnostic marker for eMF that can differentiate eMF from BIDs mimickers. | ||||
Keywords | ||||
Cutaneous T cell lymphoma; mycosis fungoides; early mycosis fungoide; benign inflammatory skin diseases; Thymocytes selection associated HMG-box | ||||
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