The role of detection of anti-HBc IgM in HBs Ag negative blood donors
Abdou, A., Hasssan, M., El Gamal, S., El dewi, D. (2020). The role of detection of anti-HBc IgM in HBs Ag negative blood donors. EKB Journal Management System, 1(2), 67-74. doi: 10.21608/jram.2020.19827.1020
Aml Abdou; marwa Hasssan; Saffiea El Gamal; Dalia El dewi. "The role of detection of anti-HBc IgM in HBs Ag negative blood donors". EKB Journal Management System, 1, 2, 2020, 67-74. doi: 10.21608/jram.2020.19827.1020
Abdou, A., Hasssan, M., El Gamal, S., El dewi, D. (2020). 'The role of detection of anti-HBc IgM in HBs Ag negative blood donors', EKB Journal Management System, 1(2), pp. 67-74. doi: 10.21608/jram.2020.19827.1020
Abdou, A., Hasssan, M., El Gamal, S., El dewi, D. The role of detection of anti-HBc IgM in HBs Ag negative blood donors. EKB Journal Management System, 2020; 1(2): 67-74. doi: 10.21608/jram.2020.19827.1020

The role of detection of anti-HBc IgM in HBs Ag negative blood donors

Journal of Recent Advances in Medicine
Article 3, Volume 1, Issue 2, July 2020, Page 67-74  XML PDF (1.18 MB)
Document Type: Original Article
DOI: 10.21608/jram.2020.19827.1020
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Authors
Aml Abdou email 1; marwa Hasssan2; Saffiea El Gamal2; Dalia El dewi3
1Microbiology and Immunology Department , Faculty of Medicine for Girls, Cairo, Al-Azhar University, Egypt.
2Microbiology and Immunology Department, Faculty of Medicine for Girls, Cairo, Al-Azhar University, Egypt.
3Clinical Pathology Department, Faculty of Medicine for Girls, Cairo, Al-Azhar University, Egypt.
Abstract
Background: Post Transfusion hepatitis B viral infection is a major problem even after adoption of mandatory screening
test, HBsAg by ELISA test in blood banks. In Egypt, HBsAg is the only HBV screening test of blood donors in most
bloods banks. However HBsAg negative blood donors does not rule out the risk of transmission of hepatitis B, as the donor
may be in the ‘window period’ or has a mutant strain. During this period, detection of the antibody to the hepatitis B core
antigen (anti-HBc) IgM type is a useful serological marker.
Objective: this study aimed to evaluate the significance of screening anti-HBc IgM for HBsAg negative blood donors to
reduce the risk of transfusion transmitted HBV infection in Egypt.
Methodology: Four hundred HBsAg negative blood donors were randomly selected from Al-Zahraa University hospital
blood bank, for further screening by anti-HBcIgM by ELISA test, then positive samples for anti-HBcIgM were tested for
HBV DNA by PCR.
Results: Nine (2.25%) out of selected 400 samples were positive for anti-HBcIgM, and 4 (1%) out of these 9 samples
Conclusion: Anti HBcAg IgM screening test should be implemented as an additional screening test for blood donors in
Egypt, to improve transfusion safety as it is an indicator of occult HBV during window period.
Keywords
HBsAg; Anti HBc IgM; HBV DNA; Window period
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