A STUDY OF IMMUNOTHERAPEUTIC EFFICACY OF TRICHINELLA SPIRALIS EXCRETORY-SECRETORY PROTEINS IN MURINE TRICHINELLOSIS | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 9, Volume 50, Issue 2, August 2020, Page 281-292 PDF (1.41 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2020.113049 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| TAHANY ABD ALLAH MOHAMED AL-ATTAR; WAFAA MOHAMED EL-KERSH; GEHAN SALAH SADEK; NANCY MAHMOUD HARBA; SALWA FOUAD OSHEIBA; REHAM MUSTAFA BRAKAT | ||||
| Department of Parasitology, Faculty of Medicine, Menoufia University, Shebin ElKom, Egypt | ||||
| Abstract | ||||
| Trichinellosis is a serious zoonotic parasitic and globally endemic disease. Benzimidazole derivatives are apparently unable to kill encapsulated larvae and its effectiveness depends on solubility, dosage of therapy, host biotransformation, selectivity patterns as well as onset of treatment after infection. Excretory- secretory (ES) proteins released by Trichinella induce a strong immune response when tested as a vaccine. The current study investigated both therapeutic and protective effects of adult worm excretory secretory protein (AW/ES), or larval excretory secretory protein (LES) on T. spiralis infected mice, conducted by parasitological, histopathological, immunohistochemical, serological and molecular investigations. Larval excretory secretory protein achieved more significant therapeutic and protective effects than adult worm excretory secretory protein in experimentally infected mice, causing reduction in larval counts and decrease in pathological changes of both muscular and intestinal tissues. It increased serum IgG OD values, decreased Foxp3 expressions and increased the mean cycle thres- hold values of muscular tissues but it had lesser effects on adult worm counts than albendazole. | ||||
| Keywords | ||||
| Mice; Trichinella spiralis; Immunotherapeutic efficacy; Excretory-secretory proteins | ||||
|
Statistics Article View: 173 PDF Download: 467 |
||||
