EFFICACY OF AZITHROMYCIN ON EXPERIMENTAL TOXOPLASMOSIS INFECTED MICE | ||||
Journal of the Egyptian Society of Parasitology | ||||
Article 10, Volume 50, Issue 2, August 2020, Page 293-299 PDF (1.21 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/jesp.2020.113050 | ||||
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Authors | ||||
MONA E. NASR1; ATEF H. ABD EL HAMID2; NAGWA S. M. ALY3; GHADA H. OMAR3; ASHRAF M. A. BARAKAT4; KAWKAB A. AHMED5; SAFAA H. YOUSSIF3; GEHAN A. RASHED3 | ||||
1Department of Parasitology, Faculty of Medicine, Benha University, Egypt | ||||
2Faculty of Medicine, Benha University, Egypt | ||||
3Department of Parasitology | ||||
4Department of Zoonotic Diseases | ||||
5Department of Pathology | ||||
Abstract | ||||
Toxoplasma gondii is an opportunistic protozoan that causes a devastating disease in immunocompromised individuals and congenitally infected neonates or children. This study evaluated the efficacy of early Azithromycin treatment of Toxoplasma gondii infected mice with cystogenic Me 49 non-virulent strain. Fifty laboratory-bred female Swiss albino mice were divided into 5 groups: G1: Non-Infected, G2: Infected non-treated, G3: Infected and treated by Azithromycin 200 mg/kg at 4th day post-infection for 3 days, G4: Infected and treated by Azithromycin 200mg/kg at 4th day post-infection for 10 days & G5: Infected and treated by Spiramycin 200mg\kg at 4th day post-infection for 2 weeks, brain cysts’ number, size and histopaholoical changes were assessed after 3 months. Treatment with Azithromycin for 10 days decreased number and size of brain cysts by 70% & 40% respectively without significant difference with Spiramycin treated mice that caused reduction by 74% & 50% respectively. Azithromycin treatment for 3 days caused the least reduction by 51% & 21% respectively and Azithromycin treatment for 10 days decreased the histo-pathological changes in cerebral toxoplasmosis. Azithromycin treatment started at 4th day post-infection was effective than Spiramycin against T. gondii infection with a significant effect on cysts count and size and brain pathological changes. Azithromycin treatment for 10 days gave better effect than 3 days. | ||||
Keywords | ||||
Mice; Azithromycin; Spiramycin; Toxoplasma gondii; Treatment | ||||
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