MYOSTATIN LEVEL IN CRF PATIENTS WITH AND WITHOUT POST-HCV CIRRHOSIS AND ITS CORRELATION WITH BMI
SALAMA, M., MAKHLOUF, M., ELESSAWY, H., EL BADRY, M., ELFOULY, H. (2020). MYOSTATIN LEVEL IN CRF PATIENTS WITH AND WITHOUT POST-HCV CIRRHOSIS AND ITS CORRELATION WITH BMI. EKB Journal Management System, 50(2), 315-321. doi: 10.21608/jesp.2020.113053
MOHAMED MAGDY SALAMA; MOHAMED ALI MAKHLOUF; HAGAR AHMED ELESSAWY; MOHAMED MOHEI EL BADRY; HEBA MAHMOUD ELFOULY. "MYOSTATIN LEVEL IN CRF PATIENTS WITH AND WITHOUT POST-HCV CIRRHOSIS AND ITS CORRELATION WITH BMI". EKB Journal Management System, 50, 2, 2020, 315-321. doi: 10.21608/jesp.2020.113053
SALAMA, M., MAKHLOUF, M., ELESSAWY, H., EL BADRY, M., ELFOULY, H. (2020). 'MYOSTATIN LEVEL IN CRF PATIENTS WITH AND WITHOUT POST-HCV CIRRHOSIS AND ITS CORRELATION WITH BMI', EKB Journal Management System, 50(2), pp. 315-321. doi: 10.21608/jesp.2020.113053
SALAMA, M., MAKHLOUF, M., ELESSAWY, H., EL BADRY, M., ELFOULY, H. MYOSTATIN LEVEL IN CRF PATIENTS WITH AND WITHOUT POST-HCV CIRRHOSIS AND ITS CORRELATION WITH BMI. EKB Journal Management System, 2020; 50(2): 315-321. doi: 10.21608/jesp.2020.113053

MYOSTATIN LEVEL IN CRF PATIENTS WITH AND WITHOUT POST-HCV CIRRHOSIS AND ITS CORRELATION WITH BMI

Journal of the Egyptian Society of Parasitology
Article 13, Volume 50, Issue 2, August 2020, Page 315-321  XML PDF (883.53 K)
Document Type: Original Article
DOI: 10.21608/jesp.2020.113053
View on SCiNiTO View on SCiNiTO
Authors
MOHAMED MAGDY SALAMA1; MOHAMED ALI MAKHLOUF1; HAGAR AHMED ELESSAWY1; MOHAMED MOHEI EL BADRY2; HEBA MAHMOUD ELFOULY3
1Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Aswan University, Aswan,Egypt
3Department of Internal Medicine, Hammoul Central Hospital, Kafr El Shaikh, Egypt
Abstract
Chronic kidney disease (CKD) is a progressive condition that may negatively affect musculoskeletal
health. Secondary sarcopenia due to CKD may be associated with mobility limitations
and elevated fall risk. Thus, it is important to investigate surrogate methods that enable
the assessment of muscle mass. Myostatin regulates synthesis and degradation of skeletal muscle
proteins and is associated with the development of sarcopenia. This study assessed the myostatin
level in CKD patients and correlated with body mass index. This a prospective case
control study, carried out on 30 Egyptian patients with CKD (15 have post-HCV cirrhosis) attended
for dialysis in Al-Hammoul Central Hospital and 15 healthy controls. All patients were
subjected to detailed medical history and through clinical examination, abdominal ultrasound
and determination of serum myostatin level. The mean, standard deviation and chi-square were
calculated by SPSS. ROC curves were conducted to test the discriminative value of myostatin
level on sarcopenia and to detect the cut-off points. The results showed significant increase in
the serum myostatin level in hemodialysis patients. Myostatin level in post-HCV cirrhotic patients
was insignificantly higher than in non-cirrhotic patients. There was a significant negative
correlation between serum myostatin level and BMI and skeletal muscle index (SMI). ROC
curve showed that a cut off value of 39.05ng/ml can detect sarcopenia in hemodialysis patients.
Keywords
Chronic renal disease; Myostatin; HCV; BMI; Cirrhosis
Statistics
Article View: 179
PDF Download: 279