TOXOPLASMOSIS AND NEUROLOGICAL DISEASES IN CHILDREN: A SERIOUS RISK OR MERE ASSOCIATION | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 20, Volume 50, Issue 2, August 2020, Page 370-377 PDF (784.36 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2020.113060 | ||||
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| Authors | ||||
| NOHA M. AMIN1; ALY ELKAZAZ2; IMAN R. ABDEL-SHAFI1; EMAN HANY ELSEBAEI3; MAGDA SAID A. ABDELTAWAB1 | ||||
| 1Department of Medical Parasitology | ||||
| 2Department of Paediatrics | ||||
| 3Department of Public Health and Community Medicine | ||||
| Abstract | ||||
| Tracing the etiology of paediatric neurological disorders back to toxoplasmosis was often difficult and particularly challenged, depended mainly on serology in common practice. The current study evaluated the role of toxoplasmosis and oxidative stress in Egyptian children suffering from acute neurodevelopmental disorders, by seroprevalence in relation to IFN gamma in patients with positivity for IgG & IgM. The result showed that out of 155 patients, 128 (82.6%) were positive for IgG and 10 (6.5%) were positive for both IgG & IgM. Also, the serum malondialdehyde (MDA) was significantly higher in seropositive pa-tients than in seronegative ones. Six children suffered from acute toxoplasmosis showed high levels of serum IFN gamma. | ||||
| Keywords | ||||
| Toxoplasmosis; Neurological disorders; Seroprevalence; qPCR; MDA; IFN gamma | ||||
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