PHARMACOKINETICS OF CIPROFLOXACIN AND ITS INTERACTION WITH DICLOFENAC AFTER INTRAVENOUS INJECTION IN HEALTHY RABBITS | ||||
| Kafrelsheikh Veterinary Medical Journal | ||||
| Article 8, Volume 9, Issue 1, April 2011, Page 189-209 PDF (685.4 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/kvmj.2011.113534 | ||||
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| Authors | ||||
| H.M. Shaheen* 1; M.W. El-Sheikh2 | ||||
| 1Department of Pharmacology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt. | ||||
| 2Animal Health Research Institute, Tanta Provincial Lab., Egypt. | ||||
| Abstract | ||||
| The purpose of this study was to determine the pharmacokinetics and possible interactions of ciprofloxacin and diclofenac in healthy rabbits following intravenous injection. Six male adult chinchilla rabbits were used for the study. In a cross-over design (3 × 2) was used in two phases separated by a wash period (3 weeks), Ciprofloxacin was injected at a dose of 30 mg kg-1. They were given intravenously while diclofenac sodium at recommended dose at level of 1 mg kg -1, i.m. to each healthy rabbit. The concentration–time data were analyzed by two-compartmental (after i.v. dose). Plasma concentrations of ciprofloxacin were determined by HPLC. After a washout period, after the drugs were co-administered. The kinetic parameters of ciprofloxacin were significantly changed by administration of diclofenac. Based on these kinetic data, ciprofloxacin is likely to be effective in rabbits even in combination with diclofenac and suggested for treating infections caused by drug-sensitive pathogens in rabbits. | ||||
| Keywords | ||||
| Ciprofloxacin; Diclofenac; Pharmacokinetics; Rabbit; Plasma Concentration | ||||
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