Non-Alcoholic Fatty Liver Disease
AlHadyan, R., Khojah, A., AbdullahAlanazi, A., Alharbi, A., Al-Zubaidi, S., Traboulsi, Z., Alasseri, I., Algarni, A., Al-Mubarak, H., Alzahrani, A., Al Saeed, B., Alruwaili, H. (2018). Non-Alcoholic Fatty Liver Disease. EKB Journal Management System, 70(4), 570-576. doi: 10.12816/0043808
Roula Hadyan Mohammed AlHadyan; Albader Abdulhameed Y Khojah; Abdulaziz Ghareeb AbdullahAlanazi; Ahmed Nasser A Alharbi; Saeed Aqeel S Al-Zubaidi; Ziad Khodr Traboulsi; IbrahimAli I. Alasseri; Ahmad Yeanallah Algarni; Hassan Ali A Al-Mubarak; Ahmed Abdullah Y Alzahrani; Bashaier Abdalrazaq Al Saeed; Hamoud Jadan M Alruwaili. "Non-Alcoholic Fatty Liver Disease". EKB Journal Management System, 70, 4, 2018, 570-576. doi: 10.12816/0043808
AlHadyan, R., Khojah, A., AbdullahAlanazi, A., Alharbi, A., Al-Zubaidi, S., Traboulsi, Z., Alasseri, I., Algarni, A., Al-Mubarak, H., Alzahrani, A., Al Saeed, B., Alruwaili, H. (2018). 'Non-Alcoholic Fatty Liver Disease', EKB Journal Management System, 70(4), pp. 570-576. doi: 10.12816/0043808
AlHadyan, R., Khojah, A., AbdullahAlanazi, A., Alharbi, A., Al-Zubaidi, S., Traboulsi, Z., Alasseri, I., Algarni, A., Al-Mubarak, H., Alzahrani, A., Al Saeed, B., Alruwaili, H. Non-Alcoholic Fatty Liver Disease. EKB Journal Management System, 2018; 70(4): 570-576. doi: 10.12816/0043808

Non-Alcoholic Fatty Liver Disease

The Egyptian Journal of Hospital Medicine
Article 9, Volume 70, Issue 4, January 2018, Page 570-576  XML PDF (360.85 K)
Document Type: Original Article
DOI: 10.12816/0043808
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Authors
Roula Hadyan Mohammed AlHadyan1; Albader Abdulhameed Y Khojah2; Abdulaziz Ghareeb AbdullahAlanazi3; Ahmed Nasser A Alharbi4; Saeed Aqeel S Al-Zubaidi5; Ziad Khodr Traboulsi6; IbrahimAli I. Alasseri7; Ahmad Yeanallah Algarni6; Hassan Ali A Al-Mubarak8; Ahmed Abdullah Y Alzahrani9; Bashaier Abdalrazaq Al Saeed10; Hamoud Jadan M Alruwaili11
1Al-Maarefa Collages
2King Fahd General Hospital Jeddah
3Najran University
4Qassim University
5Batterjee Medical College
6King Abdulaziz University
7Majardah General Hospital, MROD
8Imam Abdulrahman Bin Faisal University
9University of Jeddah
10Ibn Sina National College
11Aljouf University
Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease that exposes patients to a great risk of emerging cardiovascular diseases and could develop to cirrhosis or hepatocellular carcinoma if left unmanaged.
Objective of the Study: this article is intended to provide an overview and explore the optimal intervention for management of NAFLD in the short and long term.
Methods: Electronic search in the scientific database from 1966 to 2017– (Medline, Embase, the Cochrane Library as well as NHS center websites were searched for English Publications were obtained from both reprint requests and by searching the database. Data extracted included authors, country, year of publication, age and sex of patients, epidemiology, geographical distribution, pathophysiology, risk factors, clinical manifestations, investigations and types of surgical treatment.
Conclusion: It was concluded from the extensive review of the literature that Lifestyle modification including diet, physical activity and controlling metabolic disorders are the cornerstone in current management of NAFLD. Nevertheless, Insulin-sensitizing agents and antioxidants, particularly thiazolidinediones and vitamin E, seem to be a very promising pharmacologic treatment for non-alcoholic steatohepatitis, yet further long-term multicenter studies need to be conducted for confirmation and assessment.
Keywords
Cirrhosis, steatosis; Steatohepatitis; metabolic syndrome, NAFLD, NASH
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