Protective Efficacy of Combined Administration of Vitamins C and Curcumin on Cypermethrin - Induced Oxidative Stress in Male Albino Rats.
Ziada, R., Nahas, A., Farag, A., Kotb, G. (2020). Protective Efficacy of Combined Administration of Vitamins C and Curcumin on Cypermethrin - Induced Oxidative Stress in Male Albino Rats.. EKB Journal Management System, 12(2), 109-118. doi: 10.21608/eajbsf.2020.113976
Reem M. Ziada; A. A. Nahas; Ahmed Farag; Gamila A. M. Kotb. "Protective Efficacy of Combined Administration of Vitamins C and Curcumin on Cypermethrin - Induced Oxidative Stress in Male Albino Rats.". EKB Journal Management System, 12, 2, 2020, 109-118. doi: 10.21608/eajbsf.2020.113976
Ziada, R., Nahas, A., Farag, A., Kotb, G. (2020). 'Protective Efficacy of Combined Administration of Vitamins C and Curcumin on Cypermethrin - Induced Oxidative Stress in Male Albino Rats.', EKB Journal Management System, 12(2), pp. 109-118. doi: 10.21608/eajbsf.2020.113976
Ziada, R., Nahas, A., Farag, A., Kotb, G. Protective Efficacy of Combined Administration of Vitamins C and Curcumin on Cypermethrin - Induced Oxidative Stress in Male Albino Rats.. EKB Journal Management System, 2020; 12(2): 109-118. doi: 10.21608/eajbsf.2020.113976

Protective Efficacy of Combined Administration of Vitamins C and Curcumin on Cypermethrin - Induced Oxidative Stress in Male Albino Rats.

Egyptian Academic Journal of Biological Sciences, F. Toxicology & Pest Control
Article 11, Volume 12, Issue 2, December 2020, Page 109-118  XML PDF (330.01 K)
Document Type: Original Article
DOI: 10.21608/eajbsf.2020.113976
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Authors
Reem M. Ziada1; A. A. Nahas1; Ahmed Farag2; Gamila A. M. Kotb1
1Mammalian and Aquatic Toxicology Department, Central Agricultural Pesticides Laboratory, Agricultural Research Center, Giza 12618, Egypt
2Plant Protection Department, Faculty of Agriculture, Zagazig University, Egypt
Abstract
Back Ground: Cypermethrin (CPM) is non-systematic type II synthetic pyrethroid, commonly used for pest control in livestock, forestry, horticulture, household, public and animal health services, private homes, and animal husbandry. By scavenging free radicals and modulating antioxidant protection mechanism, plant phytochemicals (vitamin C and Curcumin) are known to exert their protective impact,
Aim: The current research aimed to examine the ameliorative effect of combining curcumin with prevention of vitamin C against the toxic effects of cypermethrin.
Method: Four groups of ten male rats each, –ve control, +ve control group (200 mg curcumin and 100 mg vit. C/ kg bw), cypermethrin alone (200 mg / Kg bw), and cypermethrin supplemented with the protective antioxidants orally intubated for 28 - days.
Result: Oral cypermethrin induced a significant increase in MDA and PC in serum, liver and brain as the oxidant biomarkers. While the antioxidant biomarkers (CAT, GSH or SH protein) were significantly decreases in serum and brain tissues. The phase II biotransformation GST was increased significantly in brain and liver tissues. ATPase activity declined significantly in brain tissue only.
Conclusion: we can deduce that, cypermethrin induce oxidative stress in serum and organs tissues of male rats and the protective role curcumin and vit. C was more evident on serum, brain than liver.
Keywords
Cypermethrin; vitamin C and Curcumin (CMN). Rats
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