Protective effect of vitamin E against hepato-renal toxicity induced by meloxicam in rat | ||||
| Benha Veterinary Medical Journal | ||||
| Article 39, Volume 36, Issue 1, March 2019, Page 361-372 PDF (565.65 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bvmj.2019.114270 | ||||
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| Authors | ||||
| Hend Abd-Elsalam; Mohamed Kamel; Gamal EL-Din Shams | ||||
| Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Egypt | ||||
| Abstract | ||||
| In this research, we evaluated the effect of meloxicam, (NSAID) on antioxidant parameters and lipid peroxidation and liver, kidney histopathology in rats after oral administration for 21 days This study was conducted to evaluate the protective effects of vitamin E (100 mg/kg) on meloxicam possible adverse effects (0.27 mg/kg) for 21 consecutive days and its antioxidant scavenging capacity. Blood samples were collected at 1st ,7th, 14th, 21st days post-treatment and liver and kidney samples were collected at 7th,14th days post treatment to assess the protective effects of Vit. E. Our results indicated a significant increase in antioxidant enzymes CAT, SOD, GPX and a significant decrease in MDA. Also, a decrease in fatty changes of liver and a decrease in degenerative changes In hepatocytes caused by meloxicam administration, as demonstrated by hepatic histopathology. Also, showing a decrease in degenerative changes in renal tubular epithelium caused by meloxicam administration, as demonstrated by kidney histopathology | ||||
| Keywords | ||||
| Antioxidant activity; Histopathology; Meloxicam; Vitamin E | ||||
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