Association between Cretinism and Prolactin Secretion
Al-khayari, O., Mansour, H., lotfallah, S., Alawaji, S., Alharbi, A., Fallatah, S., Bahatab, A., Hakami, F., Enani, A., Bilal, H., Al-Mubarak, F., Almutairi, R. (2018). Association between Cretinism and Prolactin Secretion. EKB Journal Management System, 70(3), 464-468. doi: 10.12816/0043488
Omar Ahmad Almontasser Al-khayari; Hebah Adel Mansour; Safiya Ali Ahmed lotfallah; Sulaiman Abdullah Alawaji; Abdulrahman Bader Alharbi; Sarah Abdulaziz Hamid Fallatah; Ahmed Abdullah Ahmed Bahatab; Fahad Yahya Ahmad Hakami; Anouf Fawzi Enani; Hafsa Ibrahim Bilal; Fatimah Shafiq Al-Mubarak; Rami Mohammed Hamed Almutairi. "Association between Cretinism and Prolactin Secretion". EKB Journal Management System, 70, 3, 2018, 464-468. doi: 10.12816/0043488
Al-khayari, O., Mansour, H., lotfallah, S., Alawaji, S., Alharbi, A., Fallatah, S., Bahatab, A., Hakami, F., Enani, A., Bilal, H., Al-Mubarak, F., Almutairi, R. (2018). 'Association between Cretinism and Prolactin Secretion', EKB Journal Management System, 70(3), pp. 464-468. doi: 10.12816/0043488
Al-khayari, O., Mansour, H., lotfallah, S., Alawaji, S., Alharbi, A., Fallatah, S., Bahatab, A., Hakami, F., Enani, A., Bilal, H., Al-Mubarak, F., Almutairi, R. Association between Cretinism and Prolactin Secretion. EKB Journal Management System, 2018; 70(3): 464-468. doi: 10.12816/0043488

Association between Cretinism and Prolactin Secretion

The Egyptian Journal of Hospital Medicine
Article 19, Volume 70, Issue 3, January 2018, Page 464-468  XML PDF (288.45 K)
Document Type: Original Article
DOI: 10.12816/0043488
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Authors
Omar Ahmad Almontasser Al-khayari1; Hebah Adel Mansour2; Safiya Ali Ahmed lotfallah3; Sulaiman Abdullah Alawaji4; Abdulrahman Bader Alharbi4; Sarah Abdulaziz Hamid Fallatah5; Ahmed Abdullah Ahmed Bahatab6; Fahad Yahya Ahmad Hakami7; Anouf Fawzi Enani8; Hafsa Ibrahim Bilal9; Fatimah Shafiq Al-Mubarak10; Rami Mohammed Hamed Almutairi11
1Imam Mohammed Bin Saud University
2Jeddah Eye Hospital, King Abdulaziz University
3Beirut Arab University
4Qassim University
5GP King Abdulaziz Hospital Jeddah
6Saudi National Hospital
7Sabia PHC
8Prince Sultan Primary Health Care
9Batterjee Medical College
10PHC in Al-Khober
11*Ohud* Hospital Medina
Abstract
Objective:To compare the serum prolactin level in hyperthyroid and normal control females. Hyperthyroidism is a mutual disease. Even though a direct relation has been demonstrated amid hypothyroidism and increased prolactin levels, this association has not been established for hyperthyroidism.
Materials and Methods: Cross sectional study was carried out on  cases and control groups. To select the cases, all women referred to the laboratories of Saudi National Hospital  with a thyroid-stimulating hormone (TSH) level ≤0.5 mIU/L and met the inclusion criteria were entered in the study. A total of 62 women aged 16 to 49 years were enrolled. The case group included 24 hyperthyroid women, and the control group included 38 women with normal thyroid function matched by age.
Results: The mean (SD) serum level of prolactin was 16.4 (0.96) ng/mL (95% confidence interval [CI], 15.39 ng/mL to 15.69 ng/mL) in the controls and 23.02 (1.47) ng/mL (95% CI, 22.7 ng/mL to 23.4 ng/mL) in the case subjects. Hyperprolactinemia was more common in the hyperthyroid group (16.4 [0.96] ng/mL versus 23.02 [1.47] ng/mL; P<.001). The prolactin level decreased with age. Hyperthyroidism and estradiol increased the prolactin level. After adjusting for age and estradiol, hyperthyroidism increased the serum prolactin level (P<.001).
Conclusion: The outcomes of the present study showed that hyperprolactinemia is more frequent in hyperthyroid females. Serum prolactin level can be increased in hyperthyroidism.
Keywords
Prolactin secretion; Hyperthyroidism; hyperprolactinemia
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