Safety and Efficacy of Propiverine Hydrochloride Versus Mirabegron in Treating storage Symptoms in Patients with Benign Prostatic hyperplasia
masoud, M., abouhashem, S., ali, A., elsayed, I. (2023). Safety and Efficacy of Propiverine Hydrochloride Versus Mirabegron in Treating storage Symptoms in Patients with Benign Prostatic hyperplasia. EKB Journal Management System, 29(1.2), 49-55. doi: 10.21608/zumj.2020.15654.1401
muneer abdullah masoud; safwat elsayed abouhashem; ahmed ragab ali; ibrahem ismail elsayed. "Safety and Efficacy of Propiverine Hydrochloride Versus Mirabegron in Treating storage Symptoms in Patients with Benign Prostatic hyperplasia". EKB Journal Management System, 29, 1.2, 2023, 49-55. doi: 10.21608/zumj.2020.15654.1401
masoud, M., abouhashem, S., ali, A., elsayed, I. (2023). 'Safety and Efficacy of Propiverine Hydrochloride Versus Mirabegron in Treating storage Symptoms in Patients with Benign Prostatic hyperplasia', EKB Journal Management System, 29(1.2), pp. 49-55. doi: 10.21608/zumj.2020.15654.1401
masoud, M., abouhashem, S., ali, A., elsayed, I. Safety and Efficacy of Propiverine Hydrochloride Versus Mirabegron in Treating storage Symptoms in Patients with Benign Prostatic hyperplasia. EKB Journal Management System, 2023; 29(1.2): 49-55. doi: 10.21608/zumj.2020.15654.1401

Safety and Efficacy of Propiverine Hydrochloride Versus Mirabegron in Treating storage Symptoms in Patients with Benign Prostatic hyperplasia

Zagazig University Medical Journal
Article 554, Volume 29, Issue 1.2, January 2023, Page 49-55  XML PDF (313 K)
Document Type: Original Article
DOI: 10.21608/zumj.2020.15654.1401
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Authors
muneer abdullah masoud email 1; safwat elsayed abouhashem2; ahmed ragab ali2; ibrahem ismail elsayed2
1urology,faculty of medicine,zagazig
2urology Faculty of Medicine -Zagazig University
Abstract
Background: Overactive bladder (OAB) is a syndrome characterized by the presence of urgency, with or without urinary incontinence usually with increased daytime or night-time frequency. Overactive bladder is a very prevalent condition in both female and male patients, and it is more common in older adults compared with the general population. This study amid to evaluate the safety and efficacy of mirabegron compared to propiverine for managing storage symptoms in benign prostatic hyperplasia patient. Methods: This clinical prospective, randomized comparative study was to compare the clinical efficacy and safety of Mirabegron at Urology outpatient clinic, Faculty of medicine, Zagazig University from October 2018 and April 2019. 60 patients were randomly allocated in two groups; Group (A): Patients receive (mirabegron 50mg) once daily for three months. Group (B): Patients receive (Propiverine HCL 30mg) once daily for three months. Results: Propiverine and mirabegron exert similar efficacy for OAB symptoms in patients with BPH. However mirabegron seems more efficacious than Propiverine. It also represents a reasonable alternative to antimuscarinics as well as a good option for patients who should avoid potential antimuscarinic adverse effects. Conclusions: Mirabegron can be considered as adrug with the better balance between efficacy and tolerability than Propiverine.
Keywords
Overactive bladder; Propiverine Hydrochloride; Prostatic hyperplasia; Mirabegron
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