Comparative effect of extracts of Blighia sapida (Sapindaceae) from three regions on the biochemical parameters of hypertensive rats
N’GUESSAN, Y., TIEKPA, W., Adélaïde DOUE, M., TIEMOKO, C., KARAMOKO, C., BIDIE, A., KONE, D. (2020). Comparative effect of extracts of Blighia sapida (Sapindaceae) from three regions on the biochemical parameters of hypertensive rats. EKB Journal Management System, 6(2), 48-57. doi: 10.21608/jbaar.2020.116129
Yao N’GUESSAN; Wawa Justine TIEKPA; Mandé Ryta Adélaïde DOUE; Cassime TIEMOKO; Chérif Moustapha KARAMOKO; Alain BIDIE; Daouda KONE. "Comparative effect of extracts of Blighia sapida (Sapindaceae) from three regions on the biochemical parameters of hypertensive rats". EKB Journal Management System, 6, 2, 2020, 48-57. doi: 10.21608/jbaar.2020.116129
N’GUESSAN, Y., TIEKPA, W., Adélaïde DOUE, M., TIEMOKO, C., KARAMOKO, C., BIDIE, A., KONE, D. (2020). 'Comparative effect of extracts of Blighia sapida (Sapindaceae) from three regions on the biochemical parameters of hypertensive rats', EKB Journal Management System, 6(2), pp. 48-57. doi: 10.21608/jbaar.2020.116129
N’GUESSAN, Y., TIEKPA, W., Adélaïde DOUE, M., TIEMOKO, C., KARAMOKO, C., BIDIE, A., KONE, D. Comparative effect of extracts of Blighia sapida (Sapindaceae) from three regions on the biochemical parameters of hypertensive rats. EKB Journal Management System, 2020; 6(2): 48-57. doi: 10.21608/jbaar.2020.116129

Comparative effect of extracts of Blighia sapida (Sapindaceae) from three regions on the biochemical parameters of hypertensive rats

Journal of Bioscience and Applied Research
Article 2, Volume 6, Issue 2, June 2020, Page 48-57  XML PDF (967.8 K)
Document Type: Original Article
DOI: 10.21608/jbaar.2020.116129
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Authors
Yao N’GUESSAN email 1; Wawa Justine TIEKPA2; Mandé Ryta Adélaïde DOUE3; Cassime TIEMOKO3; Chérif Moustapha KARAMOKO3; Alain BIDIE1; Daouda KONE4
1African Center of Excellence on Climate Change, Biodiversity and Sustainable Agriculture, Félix Houphouet-Boigny University, Abidjan, Ivory Coast/Pharmacodynamics-Biochemical Laboratory, UFR Biosciences, Félix Houphouet-Boigny University, Abidjan, Ivory Coast
2Péliforo Gon Coulibaly University, BP 1328 Korhogo, Ivory Coast
3Pharmacodynamics-Biochemical Laboratory, UFR Biosciences, Félix Houphouet-Boigny University, Abidjan, Ivory Coast
4African Center of Excellence on Climate Change, Biodiversity and Sustainable Agriculture, Félix Houphouet-Boigny University, Abidjan, Ivory Coast
Abstract
Blighia sapida is a plant with many therapeutic virtues. In Ivory Coast, this plant is widespread in several regions with different climatic conditions. The aim of our study is to compare the effects of aqueous extracts of Blighia sapida harvested in three Ivorian regions on the biochemical parameters of rats made hypertensive by a fructose diet. Rats (20) were fed a high fructose diet (70% fructose, 10% fat, 20% protein) for 30 days. Then blood pressure was measured from an armband to the tail of the rats. Finally, biochemical and lipid parameters were measured before and after the fructose-enriched diet. All rats fed the high-fructose diet had similar rates of hypertension (SBP = 160.0 ± 0.07 mmHg; DBP = 141.5 ± 1.21 mmHg; HR = 325.7 ± 1.52 beats/min) and a change in dosing parameters. Aqueous extracts of Blighia sapida from Adzopé (EAA) and Korhogo (EAK) administered to hypertensive rats normalized the previously increased cardiovascular, biochemical, and lipid parameters compared to control rats (healthy and untreated diseased rats). However, the aqueous extract of Blighia sapida of Adzopé (EAA) showed the best effects on hypertension compared to the aqueous extract of Blighia sapida of Korhogo (EAK). Indeed, the more humid the region and the climate, the more effective the extract is. The regulating effect of aqueous extracts of Blighia sapida on blood pressure, therefore, differs from one region to another with different climatic conditions. This would explain its use in traditional medicine in certain climatic zones compared to others where its therapeutic effects would be unknown because less. Adzopé would, therefore, be the best region where Blighia sapida should be harvested for the optimal treatment of high blood pressure.
Keywords
Blighia sapida; biochemical parameters; hypertension; Sapaindacee
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