Diagnosis of Breast Micro calcifications with Contrast Enhanced Digital Mammography and Histopathological Correlation | ||||
| The Medical Journal of Cairo University | ||||
| Article 15, Volume 88, September, September 2020, Page 1561-1569 PDF (480.91 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2020.116249 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| HANA HAMDY NASSEF, M.D.; AMIR LOUIS LOUKA, M.D.; AMIRA LOTAIF ABDULLAH, M.Sc. | ||||
| The Department of Radiodiagnosis, Faculty of Medicine, Ain Shams University | ||||
| Abstract | ||||
| Abstract Backgroud: Microcalcificaitons constitute up to 31% of lesions detected at screening mammography. Ductal carcinoma in situ (DCIS) often presents with microcalcificaitons on mammography. Of all mammographically detected DCIS lesions, up to 79% manifest with microcalcifications only. However, not all microcalficications are associated with in situ or malignant disease. Aim of Study: To evaluate diagnostic value of contrast enhanced digital mammography in breast microcalcificaations. Methods: A retrospective study of 30 patients having mammographic suspicious breast calcifications under BIRADS 4, 5 and 6 categories. A high-energy and a low-energy digital mammograms were obtained and then images were subtracted, isolating the iodine signal in the region of angiogenesis. 1.5mg/kg of the contrast agent was injected by hand over a period of 1 minute at a rate of 3mL per second, followed by a saline solution flush. Breast compression was applied to reduce the thickness of the breast and images obtained exactly 2 min after contrast administration. Image acquisitions: Cranio-caudal and the medio-lateral oblique projections for the abnormal breast were obtained exactly 2 minutes after contrast injection followed by cranio-caudal and medio-lateral oblique projections of the normal breast. The lesions were analyzed by specialized radiologist for the presence, morphology, and pattern of enhancement. Finally, Correlation with histopatho-logical findings was done. Results: The sensitivity of CEDM in detecting malignant pathology with contrast uptake was 96%. Compared to sensi-tivity of 86.7% in FFDM. There were lesions of IDC in (69.2%), lesion of DCIS in (11.5%), lesion of IDCS & IDC in (11.5%) and lesions of ILC in (3.8%). Enhancement was also observed in 3/4 (75%) of the benign lesions. Conclusion: Dual-energy contrast-enhanced digital mam-mography is a useful technique in the diagnosis of underlying disease in mammographically detected breast microcalcifica-tions. | ||||
| Keywords | ||||
| Microcalcifications; Contrast enhanced digital mammography; Ductal carcinoma insitu | ||||
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