Neutrophil and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis
Mira, S., Alkhalegy, H., Abd-Elraheem, S., Elbakry, E. (2021). Neutrophil and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis. EKB Journal Management System, 3(2), 1274-1281. doi: 10.21608/ijma.2020.21844.1069
Sara Mohamed Mira; Hany Abd-elhady Alkhalegy; Sabah Ibrahim Abd-Elraheem; Elbakry Mohamed Tharwat Elbakry. "Neutrophil and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis". EKB Journal Management System, 3, 2, 2021, 1274-1281. doi: 10.21608/ijma.2020.21844.1069
Mira, S., Alkhalegy, H., Abd-Elraheem, S., Elbakry, E. (2021). 'Neutrophil and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis', EKB Journal Management System, 3(2), pp. 1274-1281. doi: 10.21608/ijma.2020.21844.1069
Mira, S., Alkhalegy, H., Abd-Elraheem, S., Elbakry, E. Neutrophil and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis. EKB Journal Management System, 2021; 3(2): 1274-1281. doi: 10.21608/ijma.2020.21844.1069

Neutrophil and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis

International Journal of Medical Arts
Article 15, Volume 3, Issue 2, April 2021, Page 1274-1281  XML PDF (1.21 MB)
Document Type: Original Article
DOI: 10.21608/ijma.2020.21844.1069
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Authors
Sara Mohamed Mira email 1; Hany Abd-elhady Alkhalegy2; Sabah Ibrahim Abd-Elraheem3; Elbakry Mohamed Tharwat Elbakry2
1Department of Pediatrics, Ministry of Health, Egypt
2Department of Pediatrics, Damietta Faculty of Medicine, Al-Azhar University, Egypt
3Department of Clinical Pathology, Damietta Faculty of Medicine, Al-Azhar University, Egypt
Abstract
Background: Neonatal sepsis [NS] is associated with severe morbidity and mortality. Clinical manifestations range from subclinical infection to severe local or systemic infection. The diagnosis of NS remains a challenge as it has subtle and distinct signs and symptoms. Although blood culture is the gold standard in the diagnosis of NS, the search for high-sensitivity NS markers continues to overcome the drawbacks of blood cultures.   
The aim of the work: This study aimed to investigate the effectiveness of the neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in predicting early onset sepsis in neonates.
Patients and Methods: A case control study, comprised 120 newborns [60 newborns with neonatal sepsis as a case group and 60 healthy newborns as a control group], based on patient records at neonatal intensive care unit [NICU] of Al-Azhar University Hospital [Damietta], from January 2018 to January 2019. All were subjected to adequate history taking, full clinical examination, complete blood picture, C-reactive protein and blood culture. After that, neutrophil to lymphocyte ratio [NLR] and platelet to lymphocyte ratio [PLR] were calculated.
Results: NLR was significantly higher in neonates with sepsis. However, there were no association between PLR and early onset sepsis [EOS]. Although, the diagnostic cutoff value for NLR was 1.0 with 72% sensitivity, 100% specificity, there was no association between PLR and EOS.
Conclusion: NLR increases significantly in neonatal sepsis, and can be used as a marker for detection of early onset neonatal sepsis.
Keywords
Neonate; Early Onset Sepsis; Neutrophil Lymphocyte Ratio; Platelet lymphocyte ratio
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