SYNTHESIS AND BIOLOGICAL EFFECT OF SOME THIENO[2,3-D] PYRIMIDINE-4-(3H) ONE
SMEISS, N., SALEH, N., NOFEL, F., NASHWA, M. (2006). SYNTHESIS AND BIOLOGICAL EFFECT OF SOME THIENO[2,3-D] PYRIMIDINE-4-(3H) ONE. EKB Journal Management System, 17(Issue 1-A), 31-51. doi: 10.21608/absb.2006.11638
NADIA A. SMEISS; NADIA M. SALEH; FIVIAN F. NOFEL; M. S. NASHWA. "SYNTHESIS AND BIOLOGICAL EFFECT OF SOME THIENO[2,3-D] PYRIMIDINE-4-(3H) ONE". EKB Journal Management System, 17, Issue 1-A, 2006, 31-51. doi: 10.21608/absb.2006.11638
SMEISS, N., SALEH, N., NOFEL, F., NASHWA, M. (2006). 'SYNTHESIS AND BIOLOGICAL EFFECT OF SOME THIENO[2,3-D] PYRIMIDINE-4-(3H) ONE', EKB Journal Management System, 17(Issue 1-A), pp. 31-51. doi: 10.21608/absb.2006.11638
SMEISS, N., SALEH, N., NOFEL, F., NASHWA, M. SYNTHESIS AND BIOLOGICAL EFFECT OF SOME THIENO[2,3-D] PYRIMIDINE-4-(3H) ONE. EKB Journal Management System, 2006; 17(Issue 1-A): 31-51. doi: 10.21608/absb.2006.11638

SYNTHESIS AND BIOLOGICAL EFFECT OF SOME THIENO[2,3-D] PYRIMIDINE-4-(3H) ONE

Al-Azhar Bulletin of Science
Article 3, Volume 17, Issue 1-A, June 2006, Page 31-51  XML PDF (632.99 K)
Document Type: Original Article
DOI: 10.21608/absb.2006.11638
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Authors
NADIA A. SMEISS* 1; NADIA M. SALEH1; FIVIAN F. NOFEL2; M. S. NASHWA1
1Chemistry Department, Al-Azhar University (Girls), Faculty of Science, Cairo, Egypt.
2Pharmacology Department, National Research Center, Cairo, Egypt.
Abstract
Interaction of thiophene enamino ester 1a,b with the acid chloride of p-tolyl sulphonamido-N-acetic acid derivatives 2a-cafforded the corresponding amide derivatives respectively 3a-f. Hydrazinolysis of 3a-f with hydrazine hydrate yielded 4a-f. Diazotization of 1a then coupling with different amines gave 6a,b. compounds 7a,b was afforded when diazonium chloride of p-toludin or enamino thiophene 3-carboxylate (5) was reacted with compound 1a. Air oxidation of 6a yielded 8. Coupling was carried out with different amines compounds where 5 yielded 9a,b. According to Gewald method 11a-b was prepared from reaction of 10a,bwith malononitrile, From 11a,bwe can prepare compounds 13, 14a-c, 15a-c 16a,b, 17a,b, 18, 19 and 20.
The structure of these compounds was confirmed by infrared, mass, H-NMR spectra the biological activity of some compounds were discussed and found to be active.
Keywords
Biological effect; THIENO[2,3-D] PYRIMIDINE-4-(3H) ONE
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