SYNTHESIS OF SOME NEW SUBSTITUTED MERCAPTOMETHYL PYRIMIDINES OF POSSIBLE BIOLOGICAL ACTIVITY | ||||
| Al-Azhar Bulletin of Science | ||||
| Article 13, Volume 17, Issue 1-A, June 2006, Page 161-170 PDF (313.81 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/absb.2006.11648 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| NAHED ABD EL-GHAFFAR* ; NADIA DAWOOD; BAHYIA EL.SADEK | ||||
| Chemistry Department , Faculty of Science , Al-Azhar University, Nasr City, Cairo. | ||||
| Abstract | ||||
| 4,6-Diaryl-2-mercaptomethyl pyrimidine derivatives (IIa,b) and (IIIa,b) were prepared. The reaction of IIa with phenylisothiocyanate afforded the corresponding N-phenylthiocarbamoyl derivative (IV) which was used as an intermediate for the synthesis of 1,3,4-thiadiazole (V), 1,3,4-triazole-2-thione-(VII) and 1,3,4-oxadiazole (VI)-5-methyl merca-ptopyrimidines. 1,3,4-Triazol-2-thione-5-methylmercaptopyrimidine(VII) was subjected to Mannich reaction. The reaction of 2-amino 1,3,4-thioadiazole-5-methyl mercaptopyrimidine (Vb) with active methylene compounds was also studied structural assignment of the prepared compounds were based on elemental and spectral data. Some of the prepared compounds were screened in vitro for their antibacterial activity. | ||||
| Keywords | ||||
| MERCAPTOMETHYL PYRIMIDINES | ||||
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