Cytotoxicity and antibacterial activity of the blue green alga Microcystis aeruginosa extracts against human cancer cell lines and foodborne bacteria
Abdel-Rahman, G., Sultan, Y., Hassoub, M., Marrez, D. (2020). Cytotoxicity and antibacterial activity of the blue green alga Microcystis aeruginosa extracts against human cancer cell lines and foodborne bacteria. EKB Journal Management System, 63(10), 4095-4105. doi: 10.21608/ejchem.2020.42714.2862
Gomaa Abdel-Rahman; Yousef Y. Sultan; Mohamed A. Hassoub; Diaa A. Marrez. "Cytotoxicity and antibacterial activity of the blue green alga Microcystis aeruginosa extracts against human cancer cell lines and foodborne bacteria". EKB Journal Management System, 63, 10, 2020, 4095-4105. doi: 10.21608/ejchem.2020.42714.2862
Abdel-Rahman, G., Sultan, Y., Hassoub, M., Marrez, D. (2020). 'Cytotoxicity and antibacterial activity of the blue green alga Microcystis aeruginosa extracts against human cancer cell lines and foodborne bacteria', EKB Journal Management System, 63(10), pp. 4095-4105. doi: 10.21608/ejchem.2020.42714.2862
Abdel-Rahman, G., Sultan, Y., Hassoub, M., Marrez, D. Cytotoxicity and antibacterial activity of the blue green alga Microcystis aeruginosa extracts against human cancer cell lines and foodborne bacteria. EKB Journal Management System, 2020; 63(10): 4095-4105. doi: 10.21608/ejchem.2020.42714.2862

Cytotoxicity and antibacterial activity of the blue green alga Microcystis aeruginosa extracts against human cancer cell lines and foodborne bacteria

Egyptian Journal of Chemistry
Article 47, Volume 63, Issue 10, October 2020, Page 4095-4105  XML PDF (661.77 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2020.42714.2862
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Authors
Gomaa Abdel-Rahman email orcid 1; Yousef Y. Sultan1; Mohamed A. Hassoub2; Diaa A. Marrez1
1Food Toxicology and Contaminants Department, National Research Centre, Dokki, Cairo, Egypt
2Fertilization Technology Department, National Research Centre, Dokki, Cairo, Egypt
Abstract
Foodborne pathogens are one of the important biological hazards causing food spoilage. Nowadays, both research and industry are looking for natural sources of food preservatives and nutraceutical agents as an alternative of the chemical ones. Algae are one of these resources and they exist abundantly in the Egyptian aquatic environment. The algal biomass of Microcystis aeruginosa was used in the present study. Different solvents (deionized water, methanol, ethanol, acetone, chloroform, diethyl ether, ethyl acetate and hexane) were used for extraction the bioactive metabolites from M. aeruginosa. Diethyl ether extract (DEE) showed marked antibacterial activity against all tested foodborne pathogenic bacteria achieving inhibition ranged between 13.3 mm with K. pneumoniae and 29.3 mm with P. aeruginosa. The DEE extract of M. aeruginosa was fractionated using column chromatography technique. Among all fractions of diethyl ether extract, F7 had an effect against all tested bacteria. Eight compounds (9,12-Octadecadienoic acid methyl ester, Hexadecadienoic acid methyl ester, 9-Octadecadienoic acid, Nonadecane, Hexadecane, 9,12,15-Octadecadienoic acid, Octasiloxane and 10-Octadecenoic acid, methyl ester) were identified using GC/MS in such fraction. In addition to the antibacterial activity of DEE and F7, they worked as anticancer agents. Low concentration of DEE (
Keywords
Microcystis aeruginosa; Cytotoxicity; foodborne bacteria; GC/MS
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