Sansevieria: An Evaluation Of Potential Cytotoxic Activity In Reference To Metabolomic And Molecular Docking Studies
El Hawary, S., Eltantawy, M., Rabeh, M., Ali, Z., Albohy, A., Fawaz, N. (2021). Sansevieria: An Evaluation Of Potential Cytotoxic Activity In Reference To Metabolomic And Molecular Docking Studies. EKB Journal Management System, 64(2), 835-849. doi: 10.21608/ejchem.2020.43384.2877
Seham Salah Eldin El Hawary; mona Elmahdy Eltantawy; Mohamed Rabeh; Zeinab Yousef Ali; Amgad Albohy; Noha Essam Fawaz. "Sansevieria: An Evaluation Of Potential Cytotoxic Activity In Reference To Metabolomic And Molecular Docking Studies". EKB Journal Management System, 64, 2, 2021, 835-849. doi: 10.21608/ejchem.2020.43384.2877
El Hawary, S., Eltantawy, M., Rabeh, M., Ali, Z., Albohy, A., Fawaz, N. (2021). 'Sansevieria: An Evaluation Of Potential Cytotoxic Activity In Reference To Metabolomic And Molecular Docking Studies', EKB Journal Management System, 64(2), pp. 835-849. doi: 10.21608/ejchem.2020.43384.2877
El Hawary, S., Eltantawy, M., Rabeh, M., Ali, Z., Albohy, A., Fawaz, N. Sansevieria: An Evaluation Of Potential Cytotoxic Activity In Reference To Metabolomic And Molecular Docking Studies. EKB Journal Management System, 2021; 64(2): 835-849. doi: 10.21608/ejchem.2020.43384.2877

Sansevieria: An Evaluation Of Potential Cytotoxic Activity In Reference To Metabolomic And Molecular Docking Studies

Egyptian Journal of Chemistry
Article 25, Volume 64, Issue 2, February 2021, Page 835-849  XML PDF (496.95 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2020.43384.2877
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Authors
Seham Salah Eldin El Hawaryorcid 1; mona Elmahdy Eltantawy2; Mohamed Rabeh3; Zeinab Yousef Ali4; Amgad Albohyorcid 5; Noha Essam Fawaz email 6
1Pharmacognosy Department, Faculty of Pharmacy, Cairo University
2Phytochemistry lab, NODCAR, Cairo, Egypt
3Pharmacognosy department, faculty of pharmacy, Cairo university
4Department of Biochemistry, National Organization of Drug Control and Research (NODCAR), Giza, Egypt
5Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The British University in Egypt (BUE), Egypt
6National Organization of Drug Control and Research (NODCAR)
Abstract
Sansevieria trifasciata Prain. and Sansevieria suffruticosa N.E.Br. were selected to evaluate their cytotoxic activity against colon (CACO2), lung (A-549) and liver (HepG-2) carcinoma cell lines. Results indicated that S. suffruticosa N.E.Br. showed a significant cytotoxic effect on CACO2 with IC50= 30.9 ± 0.72 μg/ml. Evaluating the phenolic and flavonoid contents, S. suffruticosa N.E.Br. has higher total phenolic and flavonoid contents than S. trifasciata Prain. The phenolic content was estimated using HPLC detecting the presence of apigenin-7-glucoside and cinnamic acid only in S. suffruticosa N.E.Br. with p-hydroxybenzoic acid and p-coumaric acid being the major compounds. While, catechin and kaempferol are the major compounds detected in S. trifasciata Prain. Phytochemical investigation of ethyl acetate fractions of both species results in isolation of chlorogenic acid, kaempferol, quercetin, and catechin from S. trifasciata Prain. and apigenin-7-glucoside and rutin from S. suffruticosa N.E.Br. Isolated compounds are identified using recent spectroscopic methods. All compounds are isolated for the first time from these species.
Metabolomic profiling indicates the presence of phenolic acids, flavonoids and saponins in the alcoholic extracts of the two species. In addition, molecular docking study was done for further investigation of the possible targets involved in the cytotoxicity of the alcoholic extracts of the two Sansevieria species. The ability of some phenolic compounds to interact with EGFR cancer target site rationalizes the cytotoxic activity of S. suffruticosa N.E.Br. alcoholic extract as proven by their docking pattern and docking score.
Keywords
Sansevieria trifasciata; Sansevieria suffruticosa; cytotoxic activity; molecular docking; HPLC
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