New Approaches for the Synthesis of Thiophene Derivatives with Antitumor Activities | ||||
| Egyptian Journal of Chemistry | ||||
| Article 7, Volume 55, Issue 5, October 2012, Page 549-560 PDF (393.22 K) | ||||
| DOI: 10.21608/ejchem.2012.1173 | ||||
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| Abstract | ||||
| TETRAHYDROBENZO[B]THIOPHENE derivatives 3a,b and 5a,b were synthesized followed by the alkylation of some derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) was recorded. Some of the synthesized compounds show high inhibitory effects. | ||||
| Keywords | ||||
| THIOPHENE; Pyridine; Pyrazole and Antitumor | ||||
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