Study of Vitamin D3 Supplementation on Chronic Kidney Disease (Mineral Bone Disease (CKD – MBD) Parameters in Patients with Chronic Kidney Disease Stage 3)
Abdel Salam, M., Mohamed, M., Kamel, C., Mahmoud, A. (2017). Study of Vitamin D3 Supplementation on Chronic Kidney Disease (Mineral Bone Disease (CKD – MBD) Parameters in Patients with Chronic Kidney Disease Stage 3). EKB Journal Management System, 69(2), 1941-1949. doi: 10.12816/0040627
Mona Hosny Abdel Salam; Mohamed Mostafa Mohamed; Cherry Reda Kamel; Abdelkhalek Fouad Mahmoud. "Study of Vitamin D3 Supplementation on Chronic Kidney Disease (Mineral Bone Disease (CKD – MBD) Parameters in Patients with Chronic Kidney Disease Stage 3)". EKB Journal Management System, 69, 2, 2017, 1941-1949. doi: 10.12816/0040627
Abdel Salam, M., Mohamed, M., Kamel, C., Mahmoud, A. (2017). 'Study of Vitamin D3 Supplementation on Chronic Kidney Disease (Mineral Bone Disease (CKD – MBD) Parameters in Patients with Chronic Kidney Disease Stage 3)', EKB Journal Management System, 69(2), pp. 1941-1949. doi: 10.12816/0040627
Abdel Salam, M., Mohamed, M., Kamel, C., Mahmoud, A. Study of Vitamin D3 Supplementation on Chronic Kidney Disease (Mineral Bone Disease (CKD – MBD) Parameters in Patients with Chronic Kidney Disease Stage 3). EKB Journal Management System, 2017; 69(2): 1941-1949. doi: 10.12816/0040627

Study of Vitamin D3 Supplementation on Chronic Kidney Disease (Mineral Bone Disease (CKD – MBD) Parameters in Patients with Chronic Kidney Disease Stage 3)

The Egyptian Journal of Hospital Medicine
Article 25, Volume 69, Issue 2, October 2017, Page 1941-1949  XML PDF (302.23 K)
Document Type: Original Article
DOI: 10.12816/0040627
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Authors
Mona Hosny Abdel Salam email 1; Mohamed Mostafa Mohamed1; Cherry Reda Kamel1; Abdelkhalek Fouad Mahmoud2
1Internal Medicine Department, Faculty of Medicine, Ain Shams University
2Internal Medicine, Ministry of Health, Cairo , Egyp
Abstract
Background: Bone profile parameters are affected by decreased estimated GFR within chronic kidney disease  stage 3. We aimed to investigate if  bone  profile  parameters  response   to vitamin  D3 supplementation , within  this  stage , became  affected  by  the  presence or absence of  diabetic  state.  Materials and methods: 30 patients having chronic kidney disease (stage 3)   were  enrolled  in  the  study. 19 patients constituted non – diabetic group I and 11 patients constituted  diabetic  group II . All of them   have received vitamin D3  1000 IU  daily  for  3  months . For all patients the following measurements were  performed  before  and  after  vitamin  D3  use :CBC , ESR1 & ESR2 , blood urea , serum  creatinine , estimated  GFR , complete  urine  analysis  , serum Na , protein / creatinine  ratio , serum calcium , serum phosphorus , calcium – phosphorus  product , serum  albumin  , serum  alkaline phosphatase  ,  and  intact  serum  parathyroid  hormone. Results: Serum calcium levels have increased, while   intact parathyroid  hormone   has  decreased  within  both  groups  , with  a  more  obvious  response  within  the  diabetic  group . Serum alkaline phosphatase , serum  phosphorus , and  calcium – phosphorus  product   did  not  show  any significant   change, they were   within  their  level  after  vitamin  d3  use .ESR 1 and  ESR 2 levels were  higher  from the  start of  the study    within the  diabetic  group. Their mean  level  values   have significantly   decreased   in  a  highly  significant  way  within  this  group . Kidney function parameters  and  proteinuria  have  been  deteriorated  within  the  two  groups , being  worse  within  the  diabetic  group . Conclusion: Vitamin D3 use within stage 3 chronic renal disease patients  is  effective  for  patients  support  against  bone  mineral  disturbances  occurring  within  this  disease    .
 
Keywords
vitamin D3; CKD-MBD – Bone profile – Diabetes Mellitus – CKD stage 3
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