Synthesis, characterization and cytotoxic activity study of Cu (II), Co (II), Mn (II), Ni (II) and Cr (III) Metal Complexes with new guanidine Schiff base against the hepatocellular Carcinoma (HCAM) cancer cell | ||||
| Egyptian Journal of Chemistry | ||||
| Article 39, Volume 63, Issue 10, October 2020, Page 4005-4016 PDF (1.53 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2020.37893.2778 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Sara K. Yassin; Jasim Alshawi   ; Zainab A. M. Salih
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| Chemistry, University of Basrah, Basrah, Iraq | ||||
| Abstract | ||||
| In this research, a new guanidine ligand was synthesized from the condensation reaction of 1,2-hydrazinedicarboximidamide and indol-3-carboxaldehyde and its derived metal transition complexes of Co (II), Ni (II), Mn (II), Cu (II) and Cr (III) have been synthesized by reaction of metal chlorides with guanidine ligand in the molar ratio 2:1 (M:L). The guanidine ligand and its metal complexes were characterized by different spectroscopic and analytical techniques, these studies result suggests that the metal complexes have tetrahedral geometry. The cytotoxic activity of the guanidine Schiff base and its metal complexes were studied on hepatoma cellular carcinoma (HCAM) cell line. | ||||
| Keywords | ||||
| Guanidine-indole; Thioureas; Complexes; MTT assay | ||||
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