THE EFFECT OF SINGLE VERSUS MULTIPLE INTRA-ARTICULAR INJECTION OF SYNOVIAL FLUID MESENCHYMAL STEM CELLS ON RAT TEMPOROMANDIBULAR JOINT WITH INDUCED ARTHRITIS. BIOCHEMICAL AND HISTOLOGIC ANALYSIS
Arafat, S., Kamel, S. (2020). THE EFFECT OF SINGLE VERSUS MULTIPLE INTRA-ARTICULAR INJECTION OF SYNOVIAL FLUID MESENCHYMAL STEM CELLS ON RAT TEMPOROMANDIBULAR JOINT WITH INDUCED ARTHRITIS. BIOCHEMICAL AND HISTOLOGIC ANALYSIS. EKB Journal Management System, 66(Issue 4 - October (Oral Surgery)), 2165-2172. doi: 10.21608/edj.2020.41265.1239
Shereen Wagdy Arafat; Samah Mohamed Kamel. "THE EFFECT OF SINGLE VERSUS MULTIPLE INTRA-ARTICULAR INJECTION OF SYNOVIAL FLUID MESENCHYMAL STEM CELLS ON RAT TEMPOROMANDIBULAR JOINT WITH INDUCED ARTHRITIS. BIOCHEMICAL AND HISTOLOGIC ANALYSIS". EKB Journal Management System, 66, Issue 4 - October (Oral Surgery), 2020, 2165-2172. doi: 10.21608/edj.2020.41265.1239
Arafat, S., Kamel, S. (2020). 'THE EFFECT OF SINGLE VERSUS MULTIPLE INTRA-ARTICULAR INJECTION OF SYNOVIAL FLUID MESENCHYMAL STEM CELLS ON RAT TEMPOROMANDIBULAR JOINT WITH INDUCED ARTHRITIS. BIOCHEMICAL AND HISTOLOGIC ANALYSIS', EKB Journal Management System, 66(Issue 4 - October (Oral Surgery)), pp. 2165-2172. doi: 10.21608/edj.2020.41265.1239
Arafat, S., Kamel, S. THE EFFECT OF SINGLE VERSUS MULTIPLE INTRA-ARTICULAR INJECTION OF SYNOVIAL FLUID MESENCHYMAL STEM CELLS ON RAT TEMPOROMANDIBULAR JOINT WITH INDUCED ARTHRITIS. BIOCHEMICAL AND HISTOLOGIC ANALYSIS. EKB Journal Management System, 2020; 66(Issue 4 - October (Oral Surgery)): 2165-2172. doi: 10.21608/edj.2020.41265.1239

THE EFFECT OF SINGLE VERSUS MULTIPLE INTRA-ARTICULAR INJECTION OF SYNOVIAL FLUID MESENCHYMAL STEM CELLS ON RAT TEMPOROMANDIBULAR JOINT WITH INDUCED ARTHRITIS. BIOCHEMICAL AND HISTOLOGIC ANALYSIS

Egyptian Dental Journal
Article 10, Volume 66, Issue 4 - October (Oral Surgery), October 2020, Page 2165-2172  XML PDF (1.3 MB)
Document Type: Original Article
DOI: 10.21608/edj.2020.41265.1239
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Authors
Shereen Wagdy Arafat email orcid 1; Samah Mohamed Kamel2
1Oral Surgery Department, Faculty of Dentistry, MSA University
2Oral Biology Department, Faculty of Dentistry, MSA University
Abstract
Introduction: Osteoarthritis (OA) is the most common chronic musculoskeletal disorder. Nowadays, the role of synovial fluid mesenchymal stem cells (SF MSCs) is increasingly attributed to the treatment of Temporomandibular joint osteoarthritis. This study aimed to compare single versus multiple intra-articular injection of SFMSCs in terms of macroscopic, biochemical, and histological analysis. Material & methods: 18 young adult male 200–300 grams albino rats were used in the current study divided randomly into 3 equal groups. Group (A) comprised control in which OA was induced with no treatment, group (B) comprised MSCs single intra-articular injection group, and group (C) comprised MSCs multiple intra-articular injection group. Biochemical and histologic analysis were performed. Results: histological findings showed that both groups B, C showed regeneration of meniscus and retrodiscal tissues, but group C was superior in regeneration compared to group B. Biochemical analysis showed that TNF-α and IL-1B had the highest value in the control group, followed by the single injection group, while the lowest value was found in multiple injections group respectively. Conclusion: Multiple Intra-articular SF MSCs is a potential disease-modifying therapy for patients suffering from TMJ-OA.
Keywords
SFMSCs; Osteoarthritis; TMJ; Meniscus; cytokines
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