The association of Inflammatory markers and ICAM-1 with neurological disabilities in Relapsing Remitting Multiple Sclerosis (RRMS) patients
salah abdal-aziz, H., Roushdy Abd El-Wahed, M., Hosny El-said, H., s mohamed, W. (2023). The association of Inflammatory markers and ICAM-1 with neurological disabilities in Relapsing Remitting Multiple Sclerosis (RRMS) patients. EKB Journal Management System, 29(1.2), 80-89. doi: 10.21608/zumj.2020.36548.1901
hala salah abdal-aziz; maha Roushdy Abd El-Wahed; Hana Hosny El-said; wafaa s mohamed. "The association of Inflammatory markers and ICAM-1 with neurological disabilities in Relapsing Remitting Multiple Sclerosis (RRMS) patients". EKB Journal Management System, 29, 1.2, 2023, 80-89. doi: 10.21608/zumj.2020.36548.1901
salah abdal-aziz, H., Roushdy Abd El-Wahed, M., Hosny El-said, H., s mohamed, W. (2023). 'The association of Inflammatory markers and ICAM-1 with neurological disabilities in Relapsing Remitting Multiple Sclerosis (RRMS) patients', EKB Journal Management System, 29(1.2), pp. 80-89. doi: 10.21608/zumj.2020.36548.1901
salah abdal-aziz, H., Roushdy Abd El-Wahed, M., Hosny El-said, H., s mohamed, W. The association of Inflammatory markers and ICAM-1 with neurological disabilities in Relapsing Remitting Multiple Sclerosis (RRMS) patients. EKB Journal Management System, 2023; 29(1.2): 80-89. doi: 10.21608/zumj.2020.36548.1901

The association of Inflammatory markers and ICAM-1 with neurological disabilities in Relapsing Remitting Multiple Sclerosis (RRMS) patients

Zagazig University Medical Journal
Article 559, Volume 29, Issue 1.2, January 2023, Page 80-89  XML PDF (557.85 K)
Document Type: Review Articles
DOI: 10.21608/zumj.2020.36548.1901
View on SCiNiTO View on SCiNiTO
Authors
hala salah abdal-aziz email orcid 1; maha Roushdy Abd El-Wahed2; Hana Hosny El-said3; wafaa s mohamed4
1clinical pathology , Faculty of Medicine , Zagazig university , Zagazig , Egypt
2Professor of clinical pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
3Assistant Professor of clinical pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
4Neurology department faculty of medicine zagazig university
Abstract
The Multiple Sclerosis (MS) disease is considered as chronic, demyelinating, immune –mediated disease of the central nervous system. The immunity mediated by T-lymphocyte plays the most effective destructive process in the CNS in MS. High levels of circulating soluble form of ICAM (sICAM-1) have been detected in the serum of MS patients . The biomarker neutrophil-lymphocytic ratio (NLR) is an index , had been reported to be cheap, readily available, and easy to measyre. The estimation of immunoglobulin M (IgM) bands, which seem to be predictive for a more severe disease course with a shorter time period to the next relapse, and higher grade of disability. Also, CRP elevated in response to inflammation as acute phase protein reactant and reported that CRP can be used as useful marker for the detection of inflammation-mediated MS. Aim of work: to estimate ICAM-1 levels in remitting-relapsing multiple sclerosis during remission and to evaluate it’s correlation with neurological disability , and then assess correlation of some inflammatory markers (CRP, NLR ,IgM) with neurological disability in MS patients.
Keywords
Multiple Sclerosis; ICAM-1; inflammatory biomarkers
Statistics
Article View: 197
PDF Download: 72