The relationship between tissue transglutaminase IgA antibodies and clinical manifestations in a group of children, adolescent and adult patients with type -I diabetes mellitus
Shawky, E., Ahmad, A., El-Mazary, A., Al-Sagheer, G., Saedii, A. (2017). The relationship between tissue transglutaminase IgA antibodies and clinical manifestations in a group of children, adolescent and adult patients with type -I diabetes mellitus. EKB Journal Management System, 15(1), 17-23. doi: 10.21608/ejpa.2017.11948
Eglal M. Shawky; Assmaa K. Ahmad; Abdel-Azeem M. El-Mazary; Ghada M. Al-Sagheer; Ahmed A. Saedii. "The relationship between tissue transglutaminase IgA antibodies and clinical manifestations in a group of children, adolescent and adult patients with type -I diabetes mellitus". EKB Journal Management System, 15, 1, 2017, 17-23. doi: 10.21608/ejpa.2017.11948
Shawky, E., Ahmad, A., El-Mazary, A., Al-Sagheer, G., Saedii, A. (2017). 'The relationship between tissue transglutaminase IgA antibodies and clinical manifestations in a group of children, adolescent and adult patients with type -I diabetes mellitus', EKB Journal Management System, 15(1), pp. 17-23. doi: 10.21608/ejpa.2017.11948
Shawky, E., Ahmad, A., El-Mazary, A., Al-Sagheer, G., Saedii, A. The relationship between tissue transglutaminase IgA antibodies and clinical manifestations in a group of children, adolescent and adult patients with type -I diabetes mellitus. EKB Journal Management System, 2017; 15(1): 17-23. doi: 10.21608/ejpa.2017.11948

The relationship between tissue transglutaminase IgA antibodies and clinical manifestations in a group of children, adolescent and adult patients with type -I diabetes mellitus

The Egyptian Journal of Pediatric Allergy and Immunology
Article 4, Volume 15, Issue 1, April 2017, Page 17-23  XML PDF (226.39 K)
Document Type: Original Article
DOI: 10.21608/ejpa.2017.11948
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Authors
Eglal M. Shawky1; Assmaa K. Ahmad1; Abdel-Azeem M. El-Mazary* 2; Ghada M. Al-Sagheer1; Ahmed A. Saedii3
1Departments of Endocrinology, Internal Medicine, Faculty of Medicine, Minia University, Minia, Egypt.
2Departments of Pediatrics, Faculty of Medicine, Minia University, Minia, Egypt.
3Department Clinical Pathology, Faculty of Medicine, Minia University, Minia, Egypt.
Abstract
Background: Type-1 diabetes mellitus (T1-DM) is the commonest endocrine-metabolic disease in childhood. The prevalence of CD in type-1 DM ranges from 0.6 to 16.4% compared with 0.01–0.03% in the general population. The mechanism of association between the two diseases involves a shared genetic background of HLA genotype. Serum tissue transglutaminase IgA antibodies (tTG IgA) are considered specific and sensitive markers for screening of Celiac disease in more than 95 % of patients. Objective: Screening for the presence of serum tissue transglutaminase IgA antibodies (tTG ab) as a specific and sensitive biochemical marker for Celiac disease in patients with type-1DM and its relation to the clinical manifestations of those patients. Methods: One hundred-forty-nine patients with type-1 DM attending the out-patient clinic of endocrine and metabolism, Minia University Hospital were screened for the presence of serum tissue transglutaminase IgA antibodies during the period from March 2014 to November 2015. Results: Out of 149 patients 8 patients (5.3%) were positive for IgA tTG antibodies. They who were predominantly of female gender (75% were females). According to each age group, there were four sero-positive cases in children (with age group between 9 and ≤ 12 years); two cases in adolescents (with age group between 12 and ≤ 16 years) and two cases in adults (with age group 16-21 years). Intestinal manifestations, chronic diarrhea, recurrent abdominal pain/ distension, recurrent aphtha's stomatitis, anemia and bleeding tendency were significantly more common in seropositive cases (P=0.001, 0.001, 0.016, 0.00, 0.001and 0.04 respectively). All seropositive cases (100%) had lower BMIs than normal. There were no correlations between the tTG antibodies levels and HbA1c levels. Conclusions: The presence of tTG IgA antibodies is associated with significant changes in the clinical status of a patient with type-1 DM. Celiac disease-related manifestations like weight loss; anemia and chronic diarrhea were more common in seropositive diabetic patients. Serological screening for CD should be performed in all patients with type-1DM for early diagnosis and prevention of complications.
Keywords
Type-1 DM; tissue transglutaminase; IgA antibodies
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