The Effect of Non-Surgical Periodontal Therapy on Serum Resistin Level in Chronic Periodontitis Patients with or without Type 2 Diabetes Mellitus. | ||||
| Egyptian Dental Journal | ||||
| Article 13, Volume 66, Issue 4 - October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), October 2020, Page 2311-2321 PDF (326.21 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/edj.2020.39482.1211 | ||||
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| Authors | ||||
Weam Elbattawy   1; Sahar Mahmoud Abdel Raouf2; Shaimaa Nasr3
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| 1Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University, Cairo, Egypt | ||||
| 2Department of Oral Medicine, Faculty of Dentistry, Misr International University | ||||
| 3Department of Oral Medicine and Periodontology, Faculty of Dentistry, Fayoum University | ||||
| Abstract | ||||
| Background: Resistin is a recognized marker for chronic inflammatory conditions that could be directly linked with type 2 diabetes mellitus. This study aimed to assess serum resistin level in type 2 diabetic patients with chronic periodontitis after non-surgical periodontal therapy. Methods: Forty individuals were recruited into three groups, group I consisted of 15 diabetic patients (type-2 diabetes mellitus) with moderate to severe chronic periodontitis, and 15 non-diabetic patients with moderate to severe chronic periodontitis in group II and group III consisted of 10 non-diabetic individuals with healthy periodontium. Non-surgical periodontal therapy with supra and subgingival debridement was performed for groups I and II. Gingival index, plaque index, probing pocket depth, clinical attachment loss, serum resistin and high sensitivity C-Reactive Protein assay were recorded for groups I and II before and after treatment, while HbA1c was recorded for group I. Results: Both groups showed statistically significant improvement in all clinical periodontal parameters from baseline to 3 months with no statistically significant difference when comparing both groups throughout the clinical study. A highly statistically significant decrease in mean serum levels of resistin and CRP after treatment in each group. Additionally, a statistically significant decrease in mean HbA1c level in group I was observed after treatment. Conclusion: Non-surgical periodontal therapy was effective in improving clinical periodontal parameters, serum resistin and C-reactive protein levels after 3 months for both diabetic and non-diabetic groups. | ||||
| Keywords | ||||
| Chronic periodontitis; serum resistin; C-reactive protein; type 2 diabetes mellitus | ||||
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