Endoglin Expression as a Measure of Microvessel Density in Oral Head and Neck Cancer by Immunohistochemical Study.
Maghrabi, M., Algharyani, A. (2020). Endoglin Expression as a Measure of Microvessel Density in Oral Head and Neck Cancer by Immunohistochemical Study.. EKB Journal Management System, 66(Issue 4 - October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 2345-2352. doi: 10.21608/edj.2020.40887.1231
Marwa Mohamed Maghrabi; Asmaa Salam Algharyani. "Endoglin Expression as a Measure of Microvessel Density in Oral Head and Neck Cancer by Immunohistochemical Study.". EKB Journal Management System, 66, Issue 4 - October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2020, 2345-2352. doi: 10.21608/edj.2020.40887.1231
Maghrabi, M., Algharyani, A. (2020). 'Endoglin Expression as a Measure of Microvessel Density in Oral Head and Neck Cancer by Immunohistochemical Study.', EKB Journal Management System, 66(Issue 4 - October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 2345-2352. doi: 10.21608/edj.2020.40887.1231
Maghrabi, M., Algharyani, A. Endoglin Expression as a Measure of Microvessel Density in Oral Head and Neck Cancer by Immunohistochemical Study.. EKB Journal Management System, 2020; 66(Issue 4 - October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 2345-2352. doi: 10.21608/edj.2020.40887.1231

Endoglin Expression as a Measure of Microvessel Density in Oral Head and Neck Cancer by Immunohistochemical Study.

Egyptian Dental Journal
Article 16, Volume 66, Issue 4 - October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), October 2020, Page 2345-2352  XML PDF (1.95 MB)
Document Type: Original Article
DOI: 10.21608/edj.2020.40887.1231
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Authors
Marwa Mohamed Maghrabi email orcid 1; Asmaa Salam Algharyaniorcid 2
1Oral Pathology/ Faculty of dentistry- Tripoli University- Tripoli- Libya.
2Oral Pathology Faculty of dentistry- Tripoli University-Tripoli- Libya
Abstract
Abstract
Background and Aim:
Tumor growth is limited by the balance between the need for oxygen and nutrients and diffusion of these substances from vessels around tumors. Therefore, angiogenesis, development of new blood vessels from previous blood vessels, is necessary for tumor growth and metastasis. This study was carried out with the aim of evaluating the angiogenesis in oral cancer by assessing microvessel density (MVD) using Endoglin (CD105). This work also correlated the expressions of marker with histopathological grades of oral squamous cell carcinoma.
Material and Methods: Immunohistochemical staining with Streptavidin peroxidase was used to analyze the CD105 expression in 25 cases of oral squamous cell carcinoma.

Results: All studied cases showed positive of CD105 immunoreactivity. The study revealed a highly significant increase of CD105-MVD in poorly differentiated OSSC than well differentiated OSCC.

Conclusion: Increased expression of CD 105 in high grade tumors suggests that Endoglin is likely to contribute significantly to resistance in response to therapy.
Keywords
Key words: - Angiogenesis; Microvessel density (MVD); Endothelial cells (ECs); CD105 and Oral Squamous Cell Carcinoma (OSCC)
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