Pancreatic elastase-1 level in older individuals
Khalil, F., Negm, S., Elassal, M., Abdel Latif, W., ElAlfy, A., Afifi, M., Refaey, M. (2020). Pancreatic elastase-1 level in older individuals. EKB Journal Management System, 37(Special issue (Internal medicine and Hepatology)), 81-90. doi: 10.21608/bmfj.2020.120278
Fawzy Khalil; Sherif Negm; Mohamed Elassal; Walid Abdel Latif; Amira ElAlfy; Mohamed Afifi; Mohammed Refaey. "Pancreatic elastase-1 level in older individuals". EKB Journal Management System, 37, Special issue (Internal medicine and Hepatology), 2020, 81-90. doi: 10.21608/bmfj.2020.120278
Khalil, F., Negm, S., Elassal, M., Abdel Latif, W., ElAlfy, A., Afifi, M., Refaey, M. (2020). 'Pancreatic elastase-1 level in older individuals', EKB Journal Management System, 37(Special issue (Internal medicine and Hepatology)), pp. 81-90. doi: 10.21608/bmfj.2020.120278
Khalil, F., Negm, S., Elassal, M., Abdel Latif, W., ElAlfy, A., Afifi, M., Refaey, M. Pancreatic elastase-1 level in older individuals. EKB Journal Management System, 2020; 37(Special issue (Internal medicine and Hepatology)): 81-90. doi: 10.21608/bmfj.2020.120278

Pancreatic elastase-1 level in older individuals

Benha Medical Journal
Article 7, Volume 37, Special issue (Internal medicine and Hepatology), November 2020, Page 81-90  XML PDF (564.29 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2020.120278
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Authors
Fawzy Khalil1; Sherif Negm1; Mohamed Elassal1; Walid Abdel Latif2; Amira ElAlfy3; Mohamed Afifi3; Mohammed Refaey3
1Department of Internal Medicine, Benha faculty of medicine, Banha University, Egypt.
2Department of Clinical and Chemical Pathology, Benha faculty of medicine, Banha University, Egypt.
3Department of Internal Medicine, Benha faculty of medicine, Banha University, Egypt
Abstract
Background: Disturbances in the endocrine pancreatic function increases with age, yet the deterioration of the exocrine gland has gained less attention. With aging, the incidence of maldigestive symptoms and malnutrition increases, raising the possibility that these might be caused at least in part by inadequate pancreatic enzyme secretion due to degenerative processes of the gland. Purpose: To investigate fecal elastase-1 (FE-1) levels among over 60 years old Egyptian individuals without known gastrointestinal disease or diabetes mellitus. Methodology: FE-1 was measured by ELISA in 45 subjects divided into a case group of 35 individuals who are old age in normal status without known gastrointestinal disease, prior gastrointestinal surgery or diabetes mellitus and another control group of 10 young healthy controls. Results: There was significant difference of  FE-1 level between case and control groups with significant low median and range value of  FE-1 level in case group ,also there was significant relationship between FE-1 level and presence of dyspeptic symptoms in both case and control groups. Median and range value of FE-1 level in subjects having dyspeptic symptoms was low compared to those having no symptoms in case group. ROC curve analysis revealed that FE-1 cut off value Conclusion: These results indicate that FE-1 level correlated negatively with age and has significant relationship with dyspeptic symptoms.
Keywords
dyspeptic symptoms; exocrine pancreatic insufficiency; fecal elastase-1; pancreatic function test
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