Association between interleukin -4 gene polymorphism with the risk and disease activity of Egyptian patients with systemic lupus erythematosus
Rashad, N., said, N., Ebaid, A., abdul maksood, R., kadry, H., Ibrahim, N. (2020). Association between interleukin -4 gene polymorphism with the risk and disease activity of Egyptian patients with systemic lupus erythematosus. EKB Journal Management System, 29(1.2), 102-109. doi: 10.21608/zumj.2020.44123.1954
Nermeen Rashad; nora said; Amany M. Ebaid; rehab abdul maksood; heba kadry; Neveen Ibrahim. "Association between interleukin -4 gene polymorphism with the risk and disease activity of Egyptian patients with systemic lupus erythematosus". EKB Journal Management System, 29, 1.2, 2020, 102-109. doi: 10.21608/zumj.2020.44123.1954
Rashad, N., said, N., Ebaid, A., abdul maksood, R., kadry, H., Ibrahim, N. (2020). 'Association between interleukin -4 gene polymorphism with the risk and disease activity of Egyptian patients with systemic lupus erythematosus', EKB Journal Management System, 29(1.2), pp. 102-109. doi: 10.21608/zumj.2020.44123.1954
Rashad, N., said, N., Ebaid, A., abdul maksood, R., kadry, H., Ibrahim, N. Association between interleukin -4 gene polymorphism with the risk and disease activity of Egyptian patients with systemic lupus erythematosus. EKB Journal Management System, 2020; 29(1.2): 102-109. doi: 10.21608/zumj.2020.44123.1954

Association between interleukin -4 gene polymorphism with the risk and disease activity of Egyptian patients with systemic lupus erythematosus

Zagazig University Medical Journal
Article 563, Volume 29, Issue 1.2, January 2023, Page 102-109  XML PDF (445.05 K)
Document Type: Original Article
DOI: 10.21608/zumj.2020.44123.1954
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Authors
Nermeen Rashadorcid 1; nora said email 2; Amany M. Ebaid3; rehab abdul maksood4; heba kadry5; Neveen Ibrahim6
1Internal medicine, faculty of medicine, zagazig university
2clinical pathology,faculty of medicine departement,zagazig university
3Rheumatology and Rehabilitation department, faculty of medicine, Zagazig university
4Medical Biochemistry Department
5Medical Microbiology & Immunology Department
6Internal Medicine Department
Abstract
Background: Cytokines are a heterogeneous group of molecules organizing different processes of the immune response. Interleukin -4 (IL-4) modulates various immune functions. It plays a vital role in the development of systemic lupus erythematosus (SLE). We aimed to explore the correlation of IL-4 C-589T (rs2243250) gene polymorphism with SLE and its association with disease activity.
Method: This study included 100 SLE patients and 90 healthy controls. Disease activity was evaluated by Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Samples from all participants were analyzed for IL-4 589 genotyping by restriction fragment length polymorphism (RFLP) and serum IL-4 level by enzyme linked immunosorbent assay (ELISA).
Results: IL-4 serum level was significantly lower in patients with SLE (3.14±0.782pg/ml) compared to control (13.82±4.85 pg/ml) (p < 0.001), there was a significant negative correlation between IL-4 serum level and SLEDAI score. CT genotype distribution was significantly lower in SLE patients than controls [OR (95% CI) 0.209 (0.035- 1.246), P < 0.05*]. The frequency of the IL-4 589 T allele was 87% (174 out of 200) in the SLE group compared to 73.9% (133 out of 180) in the controls [OR (2.365 (1.392-4.016), P< 0.01.
Conclusion: CT genotype and T allele of IL-4 C-589T (rs2243250) gene can be a risk factor for SLE. Serum IL-4 level significantly correlated with SLEDAI score
Keywords
systemic lupus erythematosus; SLEDAI; IL-4 589
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