Arabic Gum Role in Ameliorating Cyclosporine- A Initiated Nephrotoxicity in Rats | ||||
| Egyptian Journal of Histology | ||||
| Article 11, Volume 44, Issue 3, September 2021, Page 710-718 PDF (3.51 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejh.2020.37873.1339 | ||||
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| Authors | ||||
Hosam-Eldin Hussein Osman1; Doaa Galal ELSahra2; Ayman El-Meghawry El-Kenawy3; Rasha R. Salem   4
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| 1Department of Anatomy, College of Medicine, Taif University, Al-Azhar University. | ||||
| 2Modern Technology and Information University. | ||||
| 3Department of Pathology, College of Medicine, Taif University,Department of molecular biology, GEBRI, University of Sadat city | ||||
| 4Anatomy department,faculty of medicine.Alexandria university | ||||
| Abstract | ||||
| Background: Recently many researchers reported that treatment using cyclosporine A in extended period in order to avoide the rejection of allograft is connected with renal impairment progress. Arabic gum is a valuable antioxidants and anti-carcinogenic factor with a protective effect against renal intoxications. Aim: This research aims at assessing the improving function of Arabic gum in ameliorating nephrotoxicity of cyclosporine A in adult rats by measuring urea and creatinine as renal function tests and histopathological changes plus redox status parameters. Materials and Methods: 80 mature rats males and females were classified into four groups during the period of expirment (45 days) first one act as control given saline; the second one was given 7.5gm/kg/day of Arabic gum ,while third group was given cyclosporine A( 25 mg/kg /day ) finally the fourth one was given 7.5gm/kg/day of Arabic gum together with the 25 mg/kg /day of cyclosporine A. Results: Cyclosporine A group three rats had renal impairment beside injury, when reported by elevated values of urea and creatinine and renal pathological changes, relative to the first group(control) with high level of cyclosporine A in blood and bad parameters of redox status. Receiving of (Arabic gum) accompanied with (cyclosporine A) ameliorating renal damage by decreasing the level of urea and creatinine in the blood, renal histo pathological amelioration, moreover the improved parametersof antioxidant. The levels of catalase, glutathione, peroxidase and superoxide dismutase were statistically reduced as regard group three G3 (cyclosporine) which was significant relative to the control & second groups G1,G2 although significantly elevated in the fourth group which given cyclosporine plus Arabic gum when compared with the third group (cyclosporine). Conclusion: Arabic gum has likely to behave like natural agent opposing cyclosporine A -provoked nephrotoxicity | ||||
| Keywords | ||||
| Arabic gum; cyclosporine A; renal impairment | ||||
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